Procedural learning impairments identified via predictive saccades in chronic traumatic brain injury.
Procedural learning impairments identified via predictive saccades in chronic traumatic brain injury.
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DOI：
10.1097/wnn.0b013e3181cefe2e
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发表时间：
2010-12
期刊：
影响因子：
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通讯作者：
Sweeney JA
中科院分区：
文献类型：
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作者：
Kraus MF;Little DM;Wojtowicz SM;Sweeney JA
探讨慢性创伤性脑损伤（TBI）患者额-纹状体回路的完整性。由于直接和间接的影响，TBI被假设为影响额叶和纹状体功能。在优雅的动物，病变和神经影像学文献的基础上，眼科测试可以提供一个有用的工具，在体内评估神经生理功能。眼功能的预测性扫视范式已经很好地建立起来，以提供对这种额-纹状体回路的评估。60例有慢性TBI病史的患者完成了2项特定的眼功能测试，包括评估基本眼功能的反射性视觉引导扫视测试和评估程序性学习的预测性扫视测试。TBI（轻度和中度/重度）与程序性学习率下降相关，损伤程度随损伤严重程度增加而增加。这被观察为预期扫视（学习的主要测量）的比例下降。这种异常的视力表现支持了这样的假设，即TBI导致额-纹状体功能的慢性损害与损伤严重程度成比例，并表明视力测试对闭合性头部损伤的所有严重程度都敏感。
To characterize integrity of fronto-striatal circuitry in chronic traumatic brain injury (TBI). Due to both direct and indirect effects, TBI is hypothesized to affect frontal and striatal function. On the basis of elegant animal, lesion, and neuroimaging literatures, oculomotor testing can provide a useful tool for in vivo assessments of neurophysiologic function. The predictive saccade paradigm in oculomotor function is well established to provide assessment of this fronto-striatal circuit. Sixty patients with a history of chronic TBI completed 2 specific tests of oculomotor function, including a test of reflexive visually guided saccades to assess basic oculomotor function and a predictive saccade test to assess procedural learning. TBI (mild and moderate/severe) was associated with a decrease in rates of procedural learning, with degree of impairment increasing with injury severity. This was observed as a decrease in the proportion of anticipatory saccades (primary measure of learning). This abnormal oculomotor performance supports the hypothesis that TBI results in chronic impairment of frontal-striatal functions proportionally to injury severity and demonstrate that oculomotor testing is sensitive to all severities of closed-head injury.