ENDOGENOUS HORMONES AND REGULATION OF UTERINE BLOOD-FLOW DURING PREGNANCY
ENDOGENOUS HORMONES AND REGULATION OF UTERINE BLOOD-FLOW DURING PREGNANCY
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DOI：
10.1152/ajpregu.1986.250.3.r365
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发表时间：
1986-03-01
影响因子：
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通讯作者：
KALRA, PS
中科院分区：
文献类型：
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作者：
CATON, D;KALRA, PS
准备了14只怀孕的绵羊，用于测量通过子宫主要动脉（UBF）的血流量以及动脉中雌激素、雌二醇和孕激素的浓度。其中5只被切除了卵巢。每天（n = 12）或每4小时测量24小时（n = 4）。UBF与激素单独或联合使用的相关系数均有统计学意义（P < 0.01）；最密切和最一致的关联是雌激素和孕激素浓度的总和或相乘。激素浓度越高的母羊UBF发生率越高。相关系数在切除卵巢的动物中更为显著。在产生生长迟缓胎儿的动物中没有发现任何关联，也没有从任何24小时的数据中发现关联。在妊娠后期，雌激素和孕激素占绵羊间和体内UBF每日变化的25%。
Fourteen pregnant sheep were prepared for measurements of blood flow through a major uterine artery (UBF) and of arterial concentrations of estrone, estradiol, and progestagen. Five of the animals were ovariectomized. Measurements were made daily (n = 12) or every 4 h for 24 h (n = 4). Statistically significant (P < 0.01) correlation coefficients were detected between UBF and hormone, either alone or in combination; the closest and most consistent associations were those in which estrogen and progestagen concentrations were summed or multiplied. Ewes with higher hormonal concentrations were those that had the higher rates of UBF. Correlation coefficients were statistically significant more often among ovariectomized animals. No associations were detected within one animal that delivered a growth-retarded fetus nor from any of the 24-h data. Estrogens and progestagen accounted for as much as 25% of the daily variation of UBF among and within sheep during the last half of pregnancy.