Catalytic, asymmetric, aldol/O-conjugate addition sequence for the construction of highly substituted furanoids.
Catalytic, asymmetric, aldol/O-conjugate addition sequence for the construction of highly substituted furanoids.
复制标题
用于构建高度取代的呋喃类化合物的催化、不对称、羟醛/O-共轭加成序列。
DOI：
10.1021/acs.orglett.5b00154
复制
发表时间：
2015
期刊：
影响因子：
5.2
通讯作者：
Korotkov,Alexander
中科院分区：
文献类型：
--
作者：
Calter,MichaelA;Korotkov,Alexander
发展了一种对映选择性合成高官能化二氢呋喃的新方法。该方法与中断的Feist-Be 'nary反应相关，包括2-烯-1，4-二酮与双甲酮在双（金鸡纳生物碱）嘧啶催化剂存在下的反应，以优异的产率和高的非对映体和对映体选择性得到二氢呋喃产物。
A new method for the enantioselective synthesis of highly functionalized dihydrofurans has been developed. This process, related to the interrupted Feist–Bénary reaction, involves the reaction of 2-ene 1,4-diketones with dimedone in the presence of bis(cinchona alkaloid)pyrimidine catalysts to afford dihydrofuran products in excellent yields and high diastereo- and enantioselectivities.