PILRα is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B
PILRα is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B
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DOI：
10.1016/j.cell.2008.01.043
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发表时间：
2008-03-21
期刊：
影响因子：
64.5
通讯作者：
Arase, Hisashi
中科院分区：
文献类型：
--
作者：
Satoh, Takeshi;Arii, Jun;Arase, Hisashi
糖蛋白B（gB）是单纯疱疹病毒1型（HSV-1）感染的主要成分之一。虽然已经鉴定了与糖蛋白D（gD）相关的几种细胞受体，例如疱疹病毒进入介体（HVEM）和Nectin-1，但是尚未阐明通过与gB相关介导HSV-1感染的特定分子。在这里，我们发现配对的免疫球蛋白样2型受体（PILR）α与gB相关，并且用PILR α转导的细胞变得对HSV-1感染敏感。此外，表达HVEM和PILR α的人原代细胞的HSV-1感染被抗PILR α或抗HVEM抗体阻断。我们的研究结果表明，gB和gD的细胞受体是HSV-1感染所必需的，PILR α在HSV-1感染中作为与gB相关的辅助受体发挥重要作用。这些发现揭示了HSV-1感染机制的一个关键方面。
Glycoprotein B(gB) is one of the essential components for infection by herpes simplex virus-1 (HSV-1). Although several cellular receptors that associate with glycoprotein D(gD), such as herpes virus entry mediator (HVEM) and Nectin-1, have been identified, specific molecules that mediate HSV-1 infection by associating with gB have not been elucidated. Here, we found that paired immunoglobulin-like type 2 receptor (PILR) alpha associates with gB, and cells transduced with PILR alpha become susceptible to HSV-1 infection. Furthermore, HSV-1 infection of human primary cells expressing both HVEM and PILR alpha was blocked by either anti-PILR alpha or anti-HVEM antibody. Our results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILR alpha plays an important role in HSV-1 infection as a coreceptor that associates with gB. These findings uncover a crucial aspect of the mechanism underlying HSV-1 infection.