Goal-related activity in hippocampal place cells
Goal-related activity in hippocampal place cells
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DOI：
10.1523/jneurosci.2864-06.2007
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发表时间：
2007-01-17
影响因子：
5.3
通讯作者：
Poucet, Bruno
中科院分区：
文献类型：
--
作者：
Hok, Vincent;Lenck-Santini, Pierre-Pascal;Poucet, Bruno
位置细胞是海马神经元，其放电与大鼠在其环境中的位置密切相关。位置细胞的存在导致了一种观点，即它们是一个致力于空间导航的综合神经系统的一部分，这一观点得到了位置细胞活动与空间问题解决之间的密切关系的发现的支持。为了进一步了解这种关系，我们研究了大鼠解决定位导航任务时记录的位置细胞放电。我们报告说，除了具有广泛分布的发射场，定位细胞也放电选择性，而饥饿的大鼠在一个未标记的目标位置等待释放食物颗粒。即使大鼠的行为被限制为与目标处的行为极其相似，这种放电也不会在主放电场之外的其他位置重复。因此，我们提出，位置细胞既提供了当前环境的几何表示，也反映了大鼠的期望，即它正确地位于目标。这一在线反馈的导航性能的一个关键方面，提出了由大部分的位置细胞的同步活动，积极在目标发出信号。结合其他（前额）细胞，提供目标位置的粗略编码，海马位置细胞可能因此参与神经网络，允许大鼠在空间中规划准确的轨迹。
Place cells are hippocampal neurons whose discharge is strongly related to a rat's location in its environment. The existence of place cells has led to the proposal that they are part of an integrated neural system dedicated to spatial navigation, an idea supported by the discovery of strong relationships between place cell activity and spatial problem solving. To further understand such relationships, we examined the discharge of place cells recorded while rats solved a place navigation task. We report that, in addition to having widely distributed firing fields, place cells also discharge selectively while the hungry rat waits in an unmarked goal location to release a food pellet. Such firing is not duplicated in other locations outside the main firing field even when the rat's behavior is constrained to be extremely similar to the behavior at the goal. We there fore propose that place cells provide both a geometric representation of the current environment and a reflection of the rat's expectancy that it is located correctly at the goal. This on-line feedback about a critical aspect of navigational performance is proposed to be signaled by the synchronous activity of the large fraction of place cells active at the goal. In combination with other ( prefrontal) cells that provide coarse encoding of goal location, hippocampal place cells may therefore participate in a neural network allowing the rat to plan accurate trajectories in space.