Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla
Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla
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DOI：
10.1007/s00330-008-0854-8
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发表时间：
2008-05-01
影响因子：
5.9
通讯作者：
Nakashima, Tsutomu
中科院分区：
文献类型：
--
作者：
Naganawa, Shinji;Satake, Hiroko;Nakashima, Tsutomu
鼓室内注射钆对比剂（Gd）后24小时，Gd主要分布于外淋巴间隙。三维FLAIR能区分内淋巴间隙和外淋巴间隙，但不能区分内淋巴间隙和外淋巴间隙与周围骨组织。本研究的目的是通过设置含Gd外淋巴液零点和不含Gd内淋巴液零点之间的反转时间，评价具有真实的重建的3D反转恢复涡轮自旋回波（3D-IR TSE）是否可以分离外淋巴间隙（正值）、内淋巴间隙（负值）和骨骼（接近零）的信号。对13例临床疑有内淋巴积水的患者进行了鼓室内Gd注射，并在3 T扫描。获得具有真实的重建的3D-FLAIR和3D-IR TSE。所有患者在3D-FLAIR上均可见迷路内淋巴间隙在解剖位置上呈低信号，3D-IRTSE上呈阴性信号。3D-IRTSE显示周围骨质低信号区为近零信号。3D-IRTSE显示含Gd外淋巴间隙呈高信号。总之，通过优化反转时间，可以使用具有真实的重建的3D-IR TSE在单个图像上分别可视化内淋巴空间、外淋巴空间和周围骨。
Twenty-four hours after intratympanic administration of gadolinium contrast material (Gd), the Gd was distributed mainly in the perilymphatic space. Three-dimensional FLAIR can differentiate endolymphatic space from perilymphatic space, but not from surrounding bone. The purpose of this study was to evaluate whether 3D inversion-recovery turbo spin echo (3D-IR TSE) with real reconstruction could separate the signals of perilymphatic space (positive value), endolymphatic space (negative value) and bone (near zero) by setting the inversion time between the null point of Gd-containing perilymph fluid and that of the endolymph fluid without Gd. Thirteen patients with clinically suspected endolymphatic hydrops underwent intratympanic Gd injection and were scanned at 3 T. A 3D FLAIR and 3D-IR TSE with real reconstruction were obtained. In all patients, low signal of endolymphatic space in the labyrinth on 3D FLAIR was observed in the anatomically appropriate position, and it showed negative signal on 3D-IR TSE. The low signal area of surrounding bone on 3D FLAIR showed near zero signal on 3D-IR TSE. Gd-containing perilymphatic space showed high signal on 3D-IR TSE. In conclusion, by optimizing the inversion time, endolymphatic space, perilymphatic space and surrounding bone can be separately visualized on a single image using a 3D-IR TSE with real reconstruction.