Nanoparticle encapsulation in vesicles formed by amphiphilic diblock copolymers
Nanoparticle encapsulation in vesicles formed by amphiphilic diblock copolymers
复制标题
两亲性二嵌段共聚物形成的囊泡中纳米颗粒的封装
DOI：
10.1039/c7sm01354j
复制
发表时间：
2017
期刊：
影响因子：
3.4
通讯作者：
Xie Daiqian
中科院分区：
文献类型：
--
作者：
Yang Junying;Hu Yi;Wang Rong;Xie Daiqian
我们使用耗散粒子动力学（DPD）方法研究了纳米粒子 P 和两亲性二嵌段共聚物 AB 在选择性溶剂中的共组装。通过控制纳米颗粒的浓度以及疏水嵌段与溶剂之间的相互作用参数，我们发现聚集形态可以从棒状胶束转变为盘状胶束，并进一步转变为囊泡。疏水/亲水嵌段的比例和纳米颗粒的浓度在很大程度上影响囊泡的结构特征和纳米颗粒的分散。具有较长疏水嵌段长度的共聚物更有可能形成具有较小水腔尺寸和囊泡尺寸以及较厚壁的囊泡。同时，疏水膜中的纳米颗粒往往更靠近囊泡的中心，并且它们的组织变得更加紧凑。一项重大发现发现，纳米颗粒浓度越大，水腔越小，囊泡尺寸越大。我们还可以通过改变纳米颗粒的浓度将纳米颗粒定位在球形胶束的中心或囊泡的疏水膜上。这提供了一种有效且简单的方法来制备包含纳米颗粒的尺寸控制的囊泡，预测纳米颗粒在囊泡内的定位，甚至调整纳米颗粒之间的距离。
We investigated the co-assembly of nanoparticles P and amphiphilic diblock copolymers AB in selective solvents using a dissipative particle dynamics (DPD) method. By controlling the nanoparticle concentration and the interaction parameter between the hydrophobic blocks and the solvents, we found that the aggregation morphology can be changed from rod-like micelles to disk-like micelles and further to vesicles. The ratio of the hydrophobic/hydrophilic block and the nanoparticle concentration largely affects the structural characteristics of vesicles and the dispersion of nanoparticles. Copolymers with a longer hydrophobic block length are more likely to form vesicles with a smaller aqueous cavity size and vesicle size as well as a thicker wall. At the same time, the nanoparticles in the hydrophobic membrane tend to locate closer to the center of the vesicle and they become more compactly organized. A significant discovery has found that the larger the nanoparticle concentration, the smaller the aqueous cavity and the larger the vesicle size. We can also locate the nanoparticles at the center of spherical micelles or the hydrophobic membranes of vesicles by varying the nanoparticle concentration. This provides an effective and simple method to prepare size-controlled vesicles containing nanoparticles, project the localization of nanoparticles within the vesicles, and even tune the distance between the nanoparticles.