Rheumatoid arthritis. Evidence for a genetic component to disease severity in RA.
Rheumatoid arthritis. Evidence for a genetic component to disease severity in RA.
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类风湿关节炎。
DOI：
10.1038/nrrheum.2012.74
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Raychaudhuri,Soumya
中科院分区：
文献类型：
--
作者：
Stahl,EliA;Raychaudhuri,Soumya
风湿性关节炎（RA）是部分遗传;遗传和血清学标记是已知的，赋予发展病理的风险。但是考虑到类风湿关节炎的临床异质性，我们能预测谁会发展成严重的疾病吗？糜烂性疾病进展率的遗传性已被证实，但仍需要更好的预后生物标志物。
Rheumatoid arthritis (RA) is partly heritable; genetic and serological markers are known to confer risk of developing pathology. But given clinical heterogeneity in RA, can we predict who will develop severe disease? Substantial heritability of erosive progression rates has now been identified, but better prognostic biomarkers remain wanting.