Circulating fatty acids and risk of gestational diabetes mellitus: prospective analyses in China
Circulating fatty acids and risk of gestational diabetes mellitus: prospective analyses in China
复制标题
循环脂肪酸与妊娠糖尿病风险：中国的前瞻性分析。
DOI：
10.1530/eje-21-0118
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发表时间：
2021-01-01
影响因子：
5.8
通讯作者：
Wu, Jason H. Y.
中科院分区：
文献类型：
--
作者：
Pan, Xiong-Fei;Huang, Yichao;Wu, Jason H. Y.
目的 我们旨在探讨中国孕妇妊娠早期循环脂肪酸与妊娠期糖尿病 (GDM) 之间的前瞻性关联。方法 分析基于在中国西部（336 例 GDM 病例和 672 例匹配对照）和中国中部（305 例和 305 例匹配对照）进行的两项前瞻性巢式病例对照研究。采用气相色谱-质谱法测定妊娠早期（入组时胎龄：10.4周[标准差，2.0]）和13.2周[1.0]的空腹血浆脂肪酸，并在妊娠24-28周期间根据国际妊娠期糖尿病协会研究组标准诊断GDM。在 672 名非 GDM 对照者中，还对入组时的多种代谢生物标志物（HOMA-IR [胰岛素抵抗稳态模型评估]、HbA1c、c 肽、高敏 C 反应蛋白、脂联素、瘦素和血脂）进行了测量。结果 较高水平的饱和脂肪酸 (SFA) 14:0（汇总优势比，每增加 1 个标准差为 1.41；95% 置信区间，1.25, 1.59）和 16:0（1.19；1.05，1.35）与较高的 GDM 几率相关。较高水平的 n-6 多不饱和脂肪酸 (PUFA) 18:2n-6 与较低的 GDM 几率密切相关 (0.69; 0.60, 0.80)。在非 GDM 孕妇中，较高的 SFA 14:0 和 16:0 但较低的 n-6 PUFA 18:2n-6 通常与不利的代谢状况相关。结论 我们记录了中国孕妇中 14:0 和 16:0 与 GDM 的不良关联，但 18:2n-6 与 GDM 的保护性关联。我们的研究结果强调了特定脂肪酸在 GDM 发病中的独特作用。
Objective We aimed to examine prospective associations between circulating fatty acids in early pregnancy and incident gestational diabetes mellitus (GDM) among Chinese pregnant women. Methods Analyses were based on two prospective nested case-control studies conducted in western China (336 GDM cases and 672 matched controls) and central China (305 cases and 305 matched controls). Fasting plasma fatty acids in early pregnancy (gestational age at enrollment: 10.4 weeks [standard deviation, 2.0]) and 13.2 weeks [1.0], respectively) were determined by gas chromatography-mass spectrometry, and GDM was diagnosed based on the International Association of Diabetes in Pregnancy Study Groups criteria during 24-28 weeks of gestation. Multiple metabolic biomarkers (HOMA-IR [homeostatic model assessment for insulin resistance], HbA1c, c-peptide, high-sensitivity C-reactive protein, adiponectin, leptin, and blood lipids) were additionally measured among 672 non-GDM controls at enrollment. Results Higher levels of saturated fatty acids (SFAs) 14:0 (pooled odds ratio, 1.41 for each 1-standard deviation increase; 95% confidence interval, 1.25, 1.59) and 16:0 (1.19; 1.05, 1.35) were associated with higher odds of GDM. Higher levels of n-6 polyunsaturated fatty acid (PUFA) 18:2n-6 was strongly associated with lower odds of GDM (0.69; 0.60, 0.80). In non-GDM pregnant women, higher SFAs 14:0 and 16:0 but lower n-6 PUFA 18:2n-6 were generally correlated with unfavorable metabolic profiles. Conclusions We documented adverse associations of 14:0 and 16:0 but a protective association of 18:2n-6 with GDM among Chinese pregnant women. Our findings highlight the distinct roles of specific fatty acids in the onset of GDM.