Synthesis of dibenzofurans via palladium-catalyzed phenol-directed C-H activation/C-O cyclization.
Synthesis of dibenzofurans via palladium-catalyzed phenol-directed C-H activation/C-O cyclization.
复制标题
DOI：
10.1021/ja203335u
复制
发表时间：
2011-05
影响因子：
15
通讯作者：
B. Xiao;Tian‐Jun Gong;Zhao-Jing Liu;Jing‐Hui Liu;Dong‐Fen Luo;Jun Xu;Lei Liu
中科院分区：
文献类型：
--
作者：
B. Xiao;Tian‐Jun Gong;Zhao-Jing Liu;Jing‐Hui Liu;Dong‐Fen Luo;Jun Xu;Lei Liu
在Pd（0）/Pd（II）催化下，以空气为氧化剂，对苯酚进行C-H活化/C-O环化反应。发现该过程的限制转化率的步骤是C-O还原消除而不是C-H活化。该反应可以耐受多种官能团，并且是对先前用于合成取代的二苯并呋喃的方法的补充。
A practical, Pd(0)/Pd(II)-catalyzed reaction was developed for phenol-directed C-H activation/C-O cyclization using air as an oxidant. The turnover-limiting step of the process was found to be C-O reductive elimination instead of C-H activation. This reaction can tolerate a variety of functional groups and is complementary to the previous methods for the synthesis of substituted dibenzofurans.