Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma
Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma
复制标题
DOI：
10.1016/s0360-3016(00)00585-x
复制
发表时间：
2000-09-01
影响因子：
7
通讯作者：
Verhey, LJ
中科院分区：
文献类型：
--
作者：
Xia, P;Fu, KK;Verhey, LJ
目的：比较调强放射治疗（IMRT）治疗计划与传统的治疗计划的情况下，局部晚期nasopharyngealcarcinoma.Methods和Materials：该研究的情况下，计划使用两种类型的调强放射治疗技术，以及三维适形放射治疗技术（3D-CRT），和传统的治疗方法，使用双边对立领域。结果：与常规计划相比，IMRT计划的计划剂量分布更符合肿瘤靶区的分布，与常规计划相比，IMRT计划的计划剂量分布更符合肿瘤靶区的分布，与常规计划相比，IMRT计划的计划剂量分布更符合肿瘤靶区的分布。在临床靶区（CTV）的剂量覆盖范围相似的情况下（定义为输送最小60戈伊至大于或等于CTV的95%），IMRT计划实现了更好的敏感正常组织结构保留，同时以更高的每次剂量输送最小68戈伊至大于或等于肿瘤总体积（GTV）的95%。与传统技术相比，调强放射治疗技术在治疗局部晚期鼻咽癌中提供了更好的肿瘤靶区覆盖率，同时显著更好地保留了敏感的正常组织结构。随着调强放射治疗效率的提高，调强放射治疗有望成为所有鼻咽癌的最佳治疗方法。需要进一步的研究来确定这种新模式的真正临床优势。(C)2000 Elsevier Science Inc.
Purpose: To compare intensity-modulated radiotherapy (IMRT) treatment plans with conventional treatment plans for a case of locally advanced nasopharyngeal carcinoma.Methods and Materials: The study case was planned using two types of IMRT techniques, as well as a three-dimensional conformal radiotherapy technique (3D-CRT), and a traditional treatment method using bilateral opposing fields. These four plans were compared with respect to dose conformality, dose-volume histogram (DVH), dose to the sensitive normal tissue structures, and ease of treatment delivery,Results: The planned dose distributions were more conformal to the tumor target volume in the IMRT plans than those in the conventional plans. With similar dose coverage of the clinical target volume (CTV), defined as delivery of minimum of 60 Gy to greater than or equal to 95% of CTV, the IMRT plans achieved better sensitive normal tissue structure sparing, while concomitantly delivering a minimum dose of 68 Gy to greater than or equal to 95% of the gross tumor volume (GTV) at a higher dose per fraction.Conclusions: Compared to conventional techniques, IMRT techniques provide improved tumor target coverage with significantly better sparing of sensitive normal tissue structures in the treatment of locally advanced nasopharyngeal carcinoma. With improvement of the delivery efficiency, IMRT should provide the optimal treatment for all nasopharyngeal carcinoma. Further studies are needed to establish the true clinical advantage of this new modality. (C) 2000 Elsevier Science Inc.