Genomic analysis of three Bifidobacterium species isolated from the calf gastrointestinal tract.
Genomic analysis of three Bifidobacterium species isolated from the calf gastrointestinal tract.
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DOI：
10.1038/srep30768
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发表时间：
2016-07-29
影响因子：
4.6
通讯作者：
Leahy SC
中科院分区：
文献类型：
--
作者：
Kelly WJ;Cookson AL;Altermann E;Lambie SC;Perry R;Teh KH;Otter DE;Shapiro N;Woyke T;Leahy SC
反刍动物对农业的全球价值做出了重大贡献，并依赖于复杂的微生物群落进行有效的消化。然而，很少有人知道这种微生物-宿主关系是如何发展和维持的。为了开始解决这个问题，我们已经确定了从新生小牛粪便中分离的三种双歧杆菌在新生反刍动物饮食中典型的碳水化合物上生长的能力。这些细菌的基因组序列已被确定与分析的基因组提供洞察宿主协会和鉴定的几个基因，可能介导的相互作用与反刍动物胃肠道。本研究提供了一个起点，从这里我们可以定义潜在的有益微生物在幼龄反刍动物营养中的作用，并开始影响微生物群与宿主之间的相互作用。在基因组含量中观察到的差异暗示了所分析的双歧杆菌物种之间的生态位划分以及它们成功适应这种栖息地所采用的不同策略。
Ruminant animals contribute significantly to the global value of agriculture and rely on a complex microbial community for efficient digestion. However, little is known of how this microbial-host relationship develops and is maintained. To begin to address this, we have determined the ability of three Bifidobacterium species isolated from the faeces of newborn calves to grow on carbohydrates typical of a newborn ruminant diet. Genome sequences have been determined for these bacteria with analysis of the genomes providing insights into the host association and identification of several genes that may mediate interactions with the ruminant gastrointestinal tract. The present study provides a starting point from which we can define the role of potential beneficial microbes in the nutrition of young ruminants and begin to influence the interactions between the microbiota and the host. The differences observed in genomic content hint at niche partitioning among the bifidobacterial species analysed and the different strategies they employ to successfully adapt to this habitat.