Attenuated GLP-1 secretion in obesity: Cause or consequence?
Attenuated GLP-1 secretion in obesity: Cause or consequence?
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DOI：
10.1136/gut.38.6.916
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发表时间：
1996-06-01
期刊：
影响因子：
24.5
通讯作者：
Marks, V
中科院分区：
文献类型：
--
作者：
Ranganath, LR;Beety, JM;Marks, V
背景-胰岛素样生长因子如葡萄糖依赖型胰岛素样多肽(GIP)和胰升糖素样肽-1(7-36)酰胺(GLP-1)的高分泌被认为是肥胖高胰岛素血症的原因。目的-研究GLP-1和GIP在肥胖女性和匹配的对照组中的作用。结果：肥胖者血浆GLP-1分泌对口服碳水化合物的分泌明显低于消瘦受试者，但对口服脂肪负荷的反应无明显差异。血浆GIP对碳水化合物或脂肪喂养的反应没有差异。所有受试者服用肝素后血浆GLP-1水平均明显下降。结论：肥胖者对口服碳水化合物的餐后GLP-1分泌明显减弱。GLP-1分泌减少的原因尚不清楚，尽管我们认为肥胖者GLP-1值的下降和整体GLP-1值的下降可能与血浆非酯化脂肪酸的增加有关。
Background-Hypersecretion of insulinotropic factors such as glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(7-36)amide (GLP-1) have been postulated to account for the hyperinsulinaemia of obesity.Aims-To examine the role of GLP-1 and GIP in obese women and matched controls.Subjects-Six lean and six obese women subjects matched for age.Methods-The gut hormone, plasma glucose, and serum triglyceride responses were studied over 180 minutes after oral carbohydrate and fat meals. Heparin (10 000 units) was given intravenously at 120 minutes.Results-There was pronounced attenuation of plasma GLP-1 secretion to oral carbohydrate in the obese compared with lean subjects but no such difference in response to oral fat load. There were no differences in the plasma GIP responses to-carbohydrate or fat feeding. There was an apparent fall in plasma GLP-1 values in all subjects after administration of heparin.Conclusion-Postprandial GLP-1 secretion in response to oral carbohydrate is considerably attenuated in obese subjects. The cause of this attenuation of GLP-1 secretion is not known although we suggest that both this fall and the overall reduction in GLP-1 values in obese subjects may be related to an increase in plasma non-esterified fatty acids.