Comparison of methods for analysis of clinical [C-11]raclopride studies
Comparison of methods for analysis of clinical [C-11]raclopride studies
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DOI：
10.1097/00004647-199601000-00005
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发表时间：
1996-01-01
影响因子：
6.3
通讯作者：
Frackowiak, RSJ
中科院分区：
文献类型：
--
作者：
Lammertsma, AA;Bench, CJ;Frackowiak, RSJ
使用来自抗精神病药物CP-88，05901剂量范围研究的数据，比较了5种不同的方法，用于估计人纹状体中[C-11]雷氯必利的结合潜力（B-max/K-d的测量）。使用单室和双室组织模型，以代谢物校正的血浆曲线作为输入函数，根据纹状体和小脑中的分布体积间接估计结合潜力。双组织室模型也用于直接估计结合潜力。此外，使用小脑作为间接输入函数，从参考组织隔室模型获得直接估计。最后，根据注射后晚期纹状体与小脑计数的比值计算结合潜力的估计值。所有方法的纹状体结合潜力的估计值，除了使用代谢物校正的血浆输入函数的两个组织房室模型的直接测定，彼此相关。使用平均代谢物校正仅导致该系列正常受试者的准确性略有降低。参考组织模型提供了结合潜力的估计值，其检测变化的灵敏度与需要代谢物校正血浆输入函数的方法相同。这表明，对于临床[C-11]雷氯必利研究的常规分析，不需要动脉插管。正常值的范围是显着较少的变量与参考组织的方法比简单的纹状体-小脑的比例。
Five different methods for the estimation of the binding potential, a measure of B-max/K-d, of [C-11]raclopride in human striatum were compared using data from a dose ranging study of the neuroleptic CP-88,05901. Binding potential was estimated indirectly, from distribution volumes in striatum and cerebellum, using both single- and two-tissue compartment models with a metabolite-corrected plasma curve as input function. The two-tissue compartment model was also used for a direct estimate of the binding potential. In addition, a direct estimate was obtained from the reference tissue compartment model using the cerebellum as indirect input function. Finally, an estimate of binding potential was calculated from the ratio of striatum over cerebellum counts at late times after injection. The estimates of striatum binding potential from all methods, except the direct determination using a two-tissue compartment model with metabolite-corrected plasma input function, correlated with each other. Use of an average metabolite correction resulted in only a small reduction in accuracy in this series of normal subjects. The reference tissue model provided estimates of the binding potential with the same sensitivity for detecting changes as those methods that required a metabolite-corrected plasma input function. This indicates that for routine analysis of clinical [C-11]raclopride studies, no arterial cannulation is required. The range of normal values was significantly less variable with the reference tissue method than when simple striatum-to-cerebellum ratios were used.