Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia
Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia
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DOI：
10.1016/j.neurobiolaging.2005.02.005
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发表时间：
2006-02-01
影响因子：
4.2
通讯作者：
De Deyn, PP
中科院分区：
文献类型：
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作者：
Engelborghs, S;Dermaut, B;De Deyn, PP
为了确定载脂蛋白等位基因（APOE）是否影响痴呆症（BPSD）的行为和心理体征和症状，我们发起了一项前瞻性纵向研究。包括阿尔茨海默病 (AD) (N = 186)、额颞叶痴呆 (FTD) (N = 29)、混合性痴呆 (MXD) (N = 28)、路易体痴呆 (DLB) (N = 11) 和帕金森病痴呆 (PDD) (N = 7) 患者。收集血液用于 DNA 提取和 APOE 基因分型。使用行为评估量表（Middelheim 额叶评分、阿尔茨海默病行为病理学评分量表 (Behave-AD)）在基线和此后每半年进行一次行为评估。在 FTD 患者中，我们发现 APOE epsilon 4 对 Behave-AD 总攻击性评分和集群攻击性评分的密切相关影响。 APOE epsilon 2 与 PDD/DLB 患者的 Behave-AD 集群妄想得分较高相关。没有发现 APOE 对 AD 和 MXD 患者 BPSD 的频率或严重程度有影响。 总之，考虑到 APOE epsilon 4 与攻击性 (FTD) 和 APOE epsilon 2 与妄想 (PDD/DLB) 的相关性，APOE 对 FTD 和 PDD/DLB 患者的 BPSD 具有疾病特异性影响。 (C) 2005 Elsevier Inc. 保留所有权利。
To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N = 186), frontotemporal dementia (FTD) (N=29), mixed dementia (MXD) (N= 28), dementia with Lewy bodies (DLB) (N= 11) and Parkinson's disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)).In FTD patients, we identified close dependent effects of APOE epsilon 4 on the Behave-AD total and cluster aggressiveness scores. APOE epsilon 2 was associated with a higher score on the Behave-AD cluster delusions in PDD/DLB patients. No APOE effects on frequency or severity of BPSD in AD and MXD Patients Were found.In Conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon 4 with aggression (FTD) and of APOE epsilon 2 with delusions (PDD/DLB). (C) 2005 Elsevier Inc. All rights reserved.