Macrophage infiltration predicts restenosis after coronary intervention in patients with unstable angina
Macrophage infiltration predicts restenosis after coronary intervention in patients with unstable angina
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DOI：
10.1161/01.cir.94.12.3098
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发表时间：
1996-12-15
期刊：
影响因子：
37.8
通讯作者：
Fallon, JT
中科院分区：
文献类型：
--
作者：
Moreno, PR;Bernardi, VH;Fallon, JT
背景 再狭窄仍然是经皮冠状动脉血运重建的主要限制。巨噬细胞释放细胞因子、金属蛋白酶和生长因子，可诱导平滑肌细胞迁移和增殖。我们测试了这样的假设：冠状动脉粥样斑块切除术后发生再狭窄的原发病变比不发生再狭窄的原发病变具有更多的巨噬细胞和平滑肌细胞。方法和结果确定了 50 名不稳定型心绞痛患者。在冠状动脉粥样斑块切除术组织的三色染色切片上对总面积和节段面积进行量化。通过免疫组织化学染色鉴定巨噬细胞和平滑肌细胞。 30 名患者出现再狭窄，通过定量电影血管造影定义为>50% 的狭窄直径。另外20名患者（
Background Restenosis remains the major limitation of percutaneous coronary revascularization. Macrophages release cy tokines, metalloproteinases, and growth factors that may induce smooth muscle cell migration and proliferation. We tested the hypothesis that primary lesions that develop restenosis after coronary atherectomy have more macrophages and smooth muscle cells than primary lesions that do not develop restenosis.Methods and Results Fifty patients with unstable angina were identified. Total and segmental areas were quantified on trichrome-stained sections of coronary atherectomy tissue. Macrophages and smooth muscle cells were identified by immunohistochemical staining. Restenosis, defined as >50% stenosis diameter by quantitative cineangiography, was present in 30 patients. The other 20 patients (