Combination chemotherapy for metastatic or recurrent adenocarcinoma of the cervix.
Combination chemotherapy for metastatic or recurrent adenocarcinoma of the cervix.
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用于治疗宫颈转移性或复发性腺癌的联合化疗。
DOI：
10.1200/jco.1987.5.10.1621
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
W. Roberts
中科院分区：
文献类型：
--
作者：
J. Kavanagh;D. Gershenson;L. Copeland;W. Roberts
Twenty-four patients with recurrent or widespread adenocarcinoma of the cervix were treated with combination chemotherapy. The drugs used were 5-fluorouracil (5-FU) (500 to 800 mg/m2), doxorubicin (40 to 50 mg/m2), and cisplatin (50 to 60 mg/m2). The chemotherapy was administered as a 76-hour continuous infusion via a silastic central venous catheter and repeated every 28 days. The total response rate was 42% (25% complete and 17% partial). Median duration of response was 7 months. Areas of response were usually lung and lymph node metastases. Toxicity, mainly neutropenia, was acceptable. All patients relapsed. This combination chemotherapy results in a modest response rate for a malignancy about which there is little information regarding the treatment of disseminated disease. Future studies should determine the activity of this combination administered in a bolus fashion.
