A Model Predicting Optimal Parameters for Deep Brain Stimulation in Essential Tremor
A Model Predicting Optimal Parameters for Deep Brain Stimulation in Essential Tremor
复制标题
DOI：
10.1097/wnp.0b013e318182ed44
复制
发表时间：
2008-10-01
影响因子：
2.4
通讯作者：
Grill, Warren M.
中科院分区：
文献类型：
--
作者：
Cooper, Scott E.;Kuncel, Alexis M.;Grill, Warren M.
在9例原发性震颤患者（14例丘脑）中，作者改变了丘脑深部脑刺激的频率、电压和脉宽，并量化了姿势性震颤。低频电刺激加重震颤，其作用随电压的增加而增强。高频电刺激与电压呈U型关系，在丘脑最佳电压下震颤最小，在最佳抑制电压下震颤增大，基于脑深部电刺激的震颤反应是前两个相互竞争过程的结果这一假设，作者成功地建立了震颤与电刺激电压和频率的数学模型。模型预测的最佳电压与经验测量值一致。此外，该模型基于IOW刺激频率下的测量结果，对高刺激频率下的震颤抑制进行了准确的预测。我们的研究结果表明，在大多数原发性震颤患者中，丘脑深部脑刺激抑制震颤存在一个最佳电压。最佳值因患者而异，这与电极位置有关。基于油“竞争过程”的数学模型成功地预测了个体患者的最佳电压。这支持了脑深部电刺激效应的竞争过程模型。
In nine patients with essential tremor (14 thalami), the authors varied frequency, voltage, and pulsewidth of thalamic deep brain stimulation, and quantified postural tremor. Low frequency stimulation aggravated tremor: the effect increased with increasing voltage. High frequency stimulation had a U-shaped relation to voltage, with minimum tremor at an optimal voltage characteristic of c the individual thalamus and increases in voltage beyond the optimum reduced tremor suppression.Based on the hypothesis that tremor response to deep brain stimulation resulted front two competing processes, the authors successfully modeled the relationship of tremor to voltage and frequency Of stimulation using a mathematical model. The optimum voltage predicted by the model agreed with the empirically measured value. Moreover, the model made accurate predictions at high stimulation frequency based on measurements trade at IOW stimulation frequency.Our results indicate there is an optimal voltage for tremor Suppression by thalamic deep brain stimulation in most patients with essential tremor. The Optimum varies across patients, and this is related to electrode position. A mathematical model based oil "competing processes" successfully predicts optimum voltage in individual patients. This supports a competing processes model of deep brain stimulation effects.