Novel immune modulators used in hematology: impact on NK cells.
Novel immune modulators used in hematology: impact on NK cells.
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DOI：
10.3389/fimmu.2012.00388
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发表时间：
2012
影响因子：
7.3
通讯作者：
Ullrich E
中科院分区：
文献类型：
--
作者：
Krieg S;Ullrich E
有广泛的重要药物用于治疗癌症。除了它们对肿瘤细胞的已知影响外，越来越多的证据表明它们可以调节免疫系统。免疫调节药物(IMiDS®)在多发性骨髓瘤或骨髓增生异常综合征的治疗中发挥着重要作用，已显示出抗肿瘤、抗血管生成和免疫刺激作用，特别是对自然杀伤(NK)细胞的作用。酪氨酸激酶抑制剂直接针对不同的激酶，调节效应NK细胞和肿瘤细胞上NKG2D配体(NKG2Dls)的表达。去甲基剂、组蛋白脱乙酰酶和蛋白酶体抑制剂干扰肿瘤细胞的表观遗传调节和蛋白质降解。有初步迹象表明，这些药物还通过增强TRAIL和NKG2DLS的表达，使肿瘤细胞对化疗、放射和NK细胞介导的细胞毒作用敏感。然而，这些药物也可能以剂量和时间依赖的方式损害NK细胞的功能。综上所述，本综述提供了不同的新分子对免疫系统集中NK细胞的影响的最新进展。
There is a wide range of important pharmaceuticals used in treatment of cancer. Besides their known effects on tumor cells, there is growing evidence for modulation of the immune system. Immunomodulatory drugs (IMiDs®) play an important role in the treatment of patients with multiple myeloma or myelodysplastic syndrome and have already demonstrated antitumor, anti-angiogenic, and immunostimulating effects, in particular on natural killer (NK) cells. Tyrosine kinase inhibitors are directly targeting different kinases and are known to regulate effector NK cells and expression of NKG2D ligands (NKG2DLs) on tumor cells. Demethylating agents, histone deacetylases, and proteasome inhibitors interfere with the epigenetic regulation and protein degradation of malignant cells. There are first hints that these drugs also sensitize tumor cells to chemotherapy, radiation, and NK cell-mediated cytotoxicity by enhanced expression of TRAIL and NKG2DLs. However, these pharmaceuticals may also impair NK cell function in a dose- and time-dependent manner. In summary, this review provides an update on the effects of different novel molecules on the immune system focusing NK cells.
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髓样恶性肿瘤中的脱甲基剂。
影响因子：
3.4
作者：
Garcia-Manero G
通讯作者：
Garcia-Manero G
影响因子：
78.5
作者：
Bartlett, JB;Dredge, K;Dalgleish, AG
通讯作者：
Dalgleish, AG
影响因子：
2.6
作者：
Fraser, Cara K.;Blake, Stephen J.;Hayball, John D.
通讯作者：
Hayball, John D.
DOI：
10.4049/jimmunol.0801214
发表时间：
2009-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Butler JE;Moore MB;Presnell SR;Chan HW;Chalupny NJ;Lutz CT
通讯作者：
Lutz CT
影响因子：
20.3
作者：
Goerguen, Guellue;Calabrese, Elisabetta;Anderson, Kenneth C.
通讯作者：
Anderson, Kenneth C.