Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling.
Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling.
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DOI：
10.1016/j.diff.2013.06.004
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发表时间：
2013-10
期刊：
影响因子：
2.9
通讯作者：
Wenzel, Pamela L.
中科院分区：
文献类型：
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作者：
Lee, Hyun Jung;Li, Nan;Evans, Siobahn M.;Diaz, Miguel F.;Wenzel, Pamela L.
关键词：
造血系统在发育和成年期间是动态的，在人的一生中经历无数的空间和时间转变。在许多独特的造血小生境的微环境线索不同，其特征在于不同的可溶性分子，膜结合因子，和生物物理特征，满足血液系统的不断变化的需求。过去十年的研究已经揭示了基质弹性和生物力学力在决定干细胞命运中的重要性。我们对这些因子在造血中的作用的理解仍然相对贫乏;然而，血细胞从内皮细胞的发育起源提供了一个比较模型。许多内皮机械传感器和第二信使系统也可能决定造血干细胞的命运，自我更新和归巢行为。此外，造血细胞与机械敏感性细胞类型（包括成骨细胞、内皮细胞、间充质干细胞和周细胞）的紧密接触使它们非常接近机械信号下游的旁分泌信号传导。本文综述了机械刺激激活的感受器和细胞内信号通路，并着重介绍了机械刺激通路在造血中的作用。
The hematopoietic system is dynamic during development and in adulthood, undergoing countless spatial and temporal transitions during the course of one’s life. Microenvironmental cues in the many unique hematopoietic niches differ, characterized by distinct soluble molecules, membrane-bound factors, and biophysical features that meet the changing needs of the blood system. Research from the last decade has revealed the importance of substrate elasticity and biomechanical force in determination of stem cell fate. Our understanding of the role of these factors in hematopoiesis is still relatively poor; however, the developmental origin of blood cells from the endothelium promts a model for comparison. Many endothelial mechanical sensors and second messenger systems may also determine hematopoietic stem cell fate, self renewal, and homing behaviors. Further, the intimate contact of hematopoietic cells with mechanosensitive cell types, including osteoblasts, endothelial cells, mesenchymal stem cells, and pericytes, places them in close proximity to paracrine signaling downstream of mechanical signals. The objective of this review is to present an overview of the sensors and intracellular signaling pathways activated by mechanical cues and highlight the role of mechanotransductive pathways in hematopoiesis.
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