Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig
Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig
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DOI：
10.1111/j.1365-2605.2007.00860.x
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发表时间：
2008-04-01
影响因子：
--
通讯作者：
Jorgensen, Niels
中科院分区：
文献类型：
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作者：
Paasch, Uwe;Salzbrunn, Andrea;Jorgensen, Niels
人口研究表明，很高比例的北欧男性精液质量可能非常差，根据国际标准，他们可以被归类为亚生育能力。一个问题是，北欧的数据是针对北欧国家的，还是应该被视为欧洲总体趋势的一种表达。因此，我们对在前东德(莱比锡)和西德(汉堡)长大的年轻男子的精液质量进行了前瞻性研究。为了能够进行区域间比较，我们使用了以前在北欧-波罗的海地区研究中使用的共同欧洲研究方案。来自汉堡的334名年轻男子和来自莱比锡的457名青年男子提供了精液样本，接受了体检，并提供了有关生活方式和生殖健康参数的信息。在汉堡的研究时间为2003年2月至2004年7月，在莱比锡的研究时间为2003年7月至2005年4月。来自汉堡、莱比锡和汉堡-莱比锡联合组的男性在精子密度(中位数分别为46、42和4400万/毫升)或精子总数(154、141和1.49亿)方面没有显著差异，而形态正常的精子(9.4和8.4%)和活动精子(67和81%)的差异有显著差异。先前发表的研究表明，随着精子密度降低到4000-5500万/毫升以下，以及正常的精子形态低于9-19%，生育力下降。因此，很大一部分德国年轻男性似乎精液质量受损，这可能会降低他们的自然生育力。然而，精液质量差在多大程度上导致了德国的低生育率，这一点仍有待调查。
Population studies have shown that a high proportion of Nordic men may have so poor semen quality that they can be classified as sub-fertile according to international standards. A question is whether the Nordic data are specific for the Nordic countries or they should be seen as an expression of a general trend in Europe. We therefore carried out a prospective study of semen quality of young men raised in the former East Germany (Leipzig) and West Germany (Hamburg). To enable inter-regional comparisons, we utilized a common European research protocol previously used in studies in the Nordic-Baltic region. Three hundred and thirty-four young men representative of the general population from Hamburg, and 457 from Leipzig delivered semen samples, underwent physical examinations and provided information on life-style and reproductive health parameters. The study period in Hamburg was February 2003 - July 2004, and in Leipzig July 2003 - April 2005. No significant differences were observed in sperm concentration (median 46, 42, and 44 million/mL for men from Hamburg, Leipzig and the combined Hamburg-Leipzig group respectively) or total sperm count (154, 141 and 149 million), whereas the differences for morphologically normal spermatozoa (9.4 and 8.4%) and motile spermatozoa (67 and 81%) were significantly different. Previously published studies have shown reduced fertility with decreasing sperm concentrations below 40-55 millions/mL and normal sperm morphology below 9-19%. Thus, a large fraction of young German men seem to have impaired semen quality that may reduce their natural fertility. However, it remains to be investigated to what extent poor semen quality contributes to the low German fertility rates.