Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex.
Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex.
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大鼠的视觉记忆任务揭示了海马体和鼻周皮层的重要作用。
DOI：
10.1073/pnas.0308528101
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Sutherland,RJ
中科院分区：
文献类型：
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作者：
Prusky,GT;Douglas,RM;Nelson,L;Shabanpoor,A;Sutherland,RJ
视觉识别记忆是由一组分布的神经回路，其中包括颞叶的结构。关于海马体在非空间形式的记忆中的作用的实验结果被归因于物种，任务和损伤的差异。我们已经克服了障碍，阻止了直接评估海马体在这种类型的记忆中的作用，为大鼠开发了一个非空间的，基于图片的，审判独特的，延迟匹配到样本的任务，这是一个程序模拟的标准视觉识别记忆任务中使用的灵长类动物。通过这项任务，我们证明了大鼠具有类似于灵长类动物的视觉记忆特征，并且依赖于嗅周皮层的功能。我们还发现，海马的选择性病变损害延迟依赖性视觉记忆的配置文件不同，所产生的损害嗅周皮层。这些数据表明，大鼠的视觉识别记忆系统与灵长类动物基本相似，依赖于海马体的功能。
Visual recognition memory is subserved by a distributed set of neural circuits, which include structures of the temporal lobe. Conflicting experimental results regarding the role of the hippocampus in nonspatial forms of such memories have been attributed to species, task, and lesion discrepancies. We have overcome obstacles that have prevented a direct evaluation of the role of the hippocampus in this type of memory by developing for rats a nonspatial, picture-based, trial-unique, delayed matching-to-sample task that is a procedural analogue of standard visual recognition memory tasks used in primates. With this task, we demonstrate that rats have a visual memory profile, which is analogous to that in primates and depends on the function of perirhinal cortex. We also find that selective lesions of hippocampus impair delay-dependent visual memory with a profile different from that produced by damage to the perirhinal cortex. These data demonstrate that rats have a visual recognition memory system fundamentally similar to primates that depends on the function of the hippocampus.