Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-β
Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-β
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DOI：
10.1016/j.cyto.2009.06.006
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发表时间：
2009-09-01
期刊：
影响因子：
3.8
通讯作者：
McFadden, Grant
中科院分区：
文献类型：
--
作者：
Bartee, Eric;McFadden, Grant
肿瘤坏死因子和干扰素家族成员是主要的诱导性细胞因子，起到对抗病毒感染或细胞转化的作用。最近，我们的实验室鉴定了一种新的抗病毒状态，这种状态是通过与肿瘤坏死因子和干扰素β共同作用于原代人成纤维细胞而诱导的。在这里，我们证明了这种协同状态对原代人类细胞既有抗病毒作用，又有细胞抑制作用。值得注意的是，我们观察到，广泛的转化的人类癌细胞普遍失去了诱导肿瘤坏死因子/干扰素β协同状态的能力。由三个不同的标准定义。我们假设，诱导肿瘤坏死因子/干扰素β协同状态的能力是原代细胞的独特特征，与细胞永生化和/或转化是不相容的。(C)2009爱思唯尔有限公司。保留所有权利。
Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFN beta. Here, we demonstrate that this synergistic state is both antiviral and cytostatic for primary human cells. Significantly, we observed that a wide spectrum of transformed human cancer cells have universally lost the ability to induce the TNF/IFN beta synergistic state. as defined by three separate criteria. We hypothesize that the ability to induce the TNF/IFN beta synergistic state is a unique feature of primary cells and is incompatible with cellular immortalization and/or transformation. (C) 2009 Elsevier Ltd. All rights reserved.