Pregnancy outcomes in women with rheumatoid arthritis in Washington State
Pregnancy outcomes in women with rheumatoid arthritis in Washington State
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DOI：
10.1007/s10995-006-0073-3
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发表时间：
2006-07-01
影响因子：
2.3
通讯作者：
Svec, Megan A.
中科院分区：
文献类型：
--
作者：
Reed, Susan D.;Vollan, Teresa A.;Svec, Megan A.
目的：确定类风湿性关节炎（RA）是否与不良产科或新生儿结局增加相关。研究设计和设置：华盛顿州1987年至2001年的出生记录和出院数据确定了一组患有类风湿性关节炎的妇女和一组没有类风湿性关节炎的妇女。妊娠和新生儿结局采用一般线性模型进行比较，计算近似相对风险和95%置信区间。结果：243例女性类风湿关节炎患者和2559例对照组。类风湿性关节炎妇女的婴儿剖宫产风险增加（调整的近似相对风险，aRR = 1.66，95% CI（1.22，2.26）），早产（aRR = 1.78，95%CI（1.21，2.60））和较长的出生住院时间（aRR = 1.86，95%CI（1.32，2.60））。结论：我们推测，类风湿性关节炎妇女所生婴儿剖宫产、早产和住院时间延长的风险增加可能是由于与类风湿性关节炎或用于治疗该疾病的药物相关的病理生理变化。
Objective: To determine whether rheumatoid arthritis (RA) is associated with increased adverse obstetric or neonatal outcomes. Study design and setting: Washington State birth records and hospital discharge data between 1987 and 2001 identified a cohort of women with rheumatoid arthritis and a comparison group of women without rheumatoid arthritis. Pregnancy and neonatal outcomes were compared using general linear models for common outcomes, calculating approximate relative risks and 95 % confidence intervals. Results: There were 243 women with rheumatoid arthritis and 2559 controls. Infants of women with rheumatoid arthritis had increased risk of cesarean delivery (adjusted approximate relative risk, aRR = 1.66, 95% CI (1.22, 2.26)), prematurity (aRR = 1.78, 95% CI (1.21, 2.60)), and longer birth hospitalization (aRR = 1.86, 95 % CI (1.32, 2.60)) compared to those born to women without rheumatoid arthritis. Conclusions: We speculate that the increased risks for cesarean delivery, prematurity, and longer hospitalization at birth among infants born to women with rheumatoid arthritis may be due to the pathophysiologic changes associated with rheumatoid arthritis or medications used to treat the disease.