Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence
Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence
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DOI：
10.1016/s0376-8716(97)00058-6
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发表时间：
1997-06-06
影响因子：
4.2
通讯作者：
Bauer, L
中科院分区：
文献类型：
--
作者：
Costa, L;Bauer, L
对88名戒毒住院患者（戒断1 - 6个月）和14名无药物依赖的对照者进行了静息脑电图（EEG）活动评估。根据《精神疾病诊断与统计手册》第三版修订本（DSM - III - R）标准，将患者分为四组：酒精依赖组（n = 12）、可卡因依赖组（n = 21）、海洛因依赖组（n = 19）以及酒精和可卡因双重依赖组（n = 36）。分析显示，五组受试者在高频和低频β波功率上存在显著差异，但在其他频段无差异。与无药物依赖的对照组相比，酒精依赖组和可卡因依赖组的β波功率显著更高。这些组间差异与酒精或可卡因使用的量/频率指标、家族史、人格、情绪或人口统计学特征无关。在酒精依赖和可卡因依赖患者中发现的脑电图β波的相似增加并不表明是药物的直接作用。相反，这表明存在一种共同的发病前变量，或者酒精/药物使用与其他变量之间存在复杂的相互作用。（C）1997年爱尔兰爱思唯尔科学有限公司
Resting electroencephalographic (EEG) activity was evaluated in 88 drug-dependent inpatients, abstinent 1-6 months, and 14 non-drug-dependent controls. The patients were assigned to one of four groups using DSM-III-R criteria: alcohol-dependent (It = 12), cocaine-dependent (Ii = 21), heroin-dependent (n = 19), or dual alcohol- and cocaine-dependent (n = 36). The analysis revealed significant differences between the five subject groups in high- and low-frequency beta power, but not in other frequency bands. Beta power was significantly greater in the alcohol-dependent and cocaine-dependent groups relative to non-drug-dependent controls. These group differences did not correlate with quantity/frequency measures of alcohol or cocaine use, family history, personality, mood, or demographic characteristics. The similar increases in EEG beta found in alcohol- and cocaine-dependent patients do not suggest a direct drug effect. Rather, they suggest the existence of a common premorbid variable or a complex interaction between alcohol/drug use and other variables. (C) 1997 Elsevier Science Ireland Ltd.