Influence of Growth Hormone (GH) on Content of GH in the Pituitaries of Normal Rats
Influence of Growth Hormone (GH) on Content of GH in the Pituitaries of Normal Rats
复制标题
生长激素（GH）对正常大鼠垂体GH含量的影响
DOI：
10.3181/00379727-121-30980
复制
发表时间：
1966
影响因子：
--
通讯作者：
S. Mccann
中科院分区：
文献类型：
--
作者：
L. Krulich;S. Mccann
总结通过胫骨骺软骨测定法估计，大鼠每日皮下注射大剂量（2和6 mg/100 g/天）牛GH后，垂体GH含量发生变化。首次注射GH后1天观察到垂体GH升高。该水平在6天后恢复正常，GH含量在初次注射后11天降低。注射生理盐水对垂体GH无影响。在第一次注射较高剂量的GH后6天，血糖浓度略有升高。GH组大鼠体重增加率明显高于对照组。提示大剂量外源性GH可改变腺垂体分泌GH的功能。
Summary Alterations in the content of pituitary GH as estimated by the tibial epi-physeal cartilage assay were produced in rats by the daily, subcutaneous injection of large doses (2 and 6 mg/100 g/day) of bovine GH. An elevation of pituitary GH was observed one day after the first injection of GH. This level returned towards normal after 6 days and the GH content was depressed at 11 days following the initial injection. The injection of saline was without effect on pituitary GH. Blood glucose concentration was slightly elevated at 6 days after the first injection of the higher dose of GH. The rate of weight gain of rats treated with GH was increased. It is suggested that large doses of exogenous GH may alter its secretion by the adenohypophy-sis.