Regulatory T cells in nonlymphoid tissues.
Regulatory T cells in nonlymphoid tissues.
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DOI：
10.1038/ni.2683
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发表时间：
2013-10
影响因子：
30.5
通讯作者：
Mathis D
中科院分区：
文献类型：
--
作者：
Burzyn D;Benoist C;Mathis D
Foxp3+CD4+调节性T细胞(Treg细胞)和非淋巴组织中的局部免疫反应一直被认为是协调良好的免疫系统的重要组成部分，但直到最近这两个领域的研究才开始交叉。越来越多的证据表明，Treg细胞存在于健康和疾病中的各种非淋巴组织中，它们具有独特的表型，其功能超出了经典的免疫反应调节。因此，组织Treg细胞可能为Treg细胞亚型的功能和/或表型分类增加了另一个层次。这篇综述综述了这一新领域的最新发现，讨论了关于非淋巴组织驻留的Treg细胞的起源、表型、功能和记忆的已知和未知。
Both Foxp3+CD4+ regulatory T cells (Treg cells) and local immune responses within non-lymphoid tissues have long been recognized as important elements of a well-orchestrated immune system, but only recently have these two fields of study begun to intersect. There is growing evidence that Treg cells are present in various non-lymphoid tissues in health and disease, that they have a unique phenotype, and that their functions go beyond the classical modulation of immune responses. Thus, tissular Treg cells might add yet another level to classification of the Treg cell compartment into functional and/or phenotypic subtypes. This review summarizes recent findings in this new field, discussing knowns and unknowns about the origin, phenotype, function and memory of non-lymphoid tissue-resident Treg cells.