Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population.
Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population.
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DOI：
10.4238/2013.september.10.2
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发表时间：
2013-09
期刊：
影响因子：
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通讯作者：
M. Yu;P. Zhao;X. Yan;B. Liu;Q. Zhang;R. Wang;C. Ma;X. Liang;F. Zhu;L. Gao
中科院分区：
文献类型：
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作者：
M. Yu;P. Zhao;X. Yan;B. Liu;Q. Zhang;R. Wang;C. Ma;X. Liang;F. Zhu;L. Gao
肿瘤坏死因子（Tumor necrosis factor， TNF）相关凋亡诱导配体（apoptosis-inducing ligand， TRAIL）表达于不同的组织细胞，包括胰腺和淋巴细胞，在肿瘤细胞中可选择性诱导细胞凋亡，而在大多数正常细胞中不能。TRAIL在1型糖尿病中起关键作用，并与2型糖尿病（T2DM）有关。我们最近发现T2DM的危险因素非酒精性脂肪性肝病与TRAIL （TNFSF10）基因1595C/T位点（rs1131580）的单核苷酸多态性（SNP）有关，表明T2DM可能与这种TRAIL多态性有关。本研究旨在探讨中国汉族人群中TRAIL SNP位点1595C/T （rs1131580）与T2DM易感性和T2DM生物代谢参数的关系。采用聚合酶链反应-限制性片段长度多态性方法对292例T2DM患者和266例健康对照进行rs1131580 SNP基因型分析。我们发现T2DM患者CC基因型和rs1131580 C等位基因的频率明显高于对照组。此外，CC基因型T2DM患者的甘油三酯和血清肌酐水平显著高于TT基因型患者。因此，TRAIL SNP在1595C/T （rs1131580）的CC基因型使山东省汉族人群对2型糖尿病的易感性增加。这些数据表明，该SNP位点的CC基因型与糖尿病严重程度相关，可能是T2DM预后评估的候选基因型。
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recently discovered the association of nonalcoholic fatty liver disease, a risk factor for T2DM, with a single nucleotide polymorphism (SNP) in the TRAIL (TNFSF10) gene at site 1595C/T (rs1131580), indicating the possible association of T2DM with this TRAIL polymorphism. The aim of this study was to investigate the relationship of the TRAIL SNP at site 1595C/T (rs1131580) with T2DM susceptibility and the biometabolic parameters of T2DM in a Han Chinese population. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype SNP rs1131580 in 292 patients with T2DM and 266 healthy controls. We found that the frequency of the CC genotype and that of the C allele of rs1131580 were significantly higher in T2DM patients than in the control group. Additionally, the triglyceride and serum creatinine levels of T2DM patients with the CC genotype were significantly higher than those of patients with the TT genotype. Thus, the CC genotype of the TRAIL SNP at 1595C/T (rs1131580) confers increased susceptible to T2DM in a Han Chinese population from Shandong Province. These data suggest that the CC genotype at this SNP is related to diabetic severity and it might be a candidate for the prognostic assessment of T2DM.