Early coding of visuomanual coordination during reaching in parietal area PEc
Early coding of visuomanual coordination during reaching in parietal area PEc
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DOI：
10.1152/jn.2001.85.1.462
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发表时间：
2001-01-01
影响因子：
2.5
通讯作者：
Caminiti, R
中科院分区：
文献类型：
--
作者：
Ferraina, S;Battaglia-Mayer, A;Caminiti, R
通过记录猕猴执行不同任务时PEC区的神经活动，研究了在伸手过程中眼手协调的顶叶机制，旨在评估视网膜、手和眼相关信号对神经活动的影响。所使用的任务包括：1）到达中央凹和2）到达中央凹外目标，具有恒定的眼睛位置;以及3）朝向周围目标的扫视眼睛运动和保持眼睛位置在周围目标上，与到达任务的那些相同。在所有的任务中，手和/或眼睛的运动，从一个中心位置到八个外围目标。以传统的视觉注视范式作为对照任务，评估神经元视觉感受野的位置和范围。PEc区的大部分细胞显示出与手运动方向和位置的显着关系。其中很多也和眼睛的位置有关。与扫视眼球运动的关系被发现为一个较小比例的细胞。大多数神经元被调整到与手和眼睛相关的信号的不同组合;其中一些也受到视觉信息的影响。这种信号的组合可以是不同形式的视觉协调的运动命令组成的早期阶段的表达，这些视觉协调取决于手和眼睛相关信息的整合。这些结果分配到区域PEC，经典地被认为是一个躯体感觉关联皮层，一个新的视觉功能的作用。
The parietal mechanisms of eye-hand coordination during reaching were studied by recording neural activity in area PEc while monkeys performed different tasks, aimed at assessing the influence of retinal, hand-, and eye-related signals on neural activity. The tasks used consisted of 1) reaching to foveated and 2) to extra-foveal targets, with constant eye position; and 3) saccadic eye movement toward, and holding of eye position on peripheral targets, the same as those of the reaching tasks. In all tasks, hand and/or eye movements were made from a central position to eight peripheral targets. A conventional visual fixation paradigm was used as a control task, to assess location and extent of visual receptive field of neurons. A large proportion of cells in area PEc displayed significant relationships to hand movement direction and position. Many of them were also related to the eye's position. Relationships to saccadic eye movements were found for a smaller proportion of cells. Most neurons were tuned to different combination of hand- and eye-related signals; some of them were also influenced by visual information. This combination of signals can be an expression of the early stages of the composition of motor commands for different forms of visuomotor coordination that depend on the integration of hand- and eye-related information. These results assign to area PEc, classically considered as a somatosensory association cortex, a new visuomotor role.