Detection of host immune responses in acute phase sera of spontaneous resolution versus persistent hepatitis C virus infection.
Detection of host immune responses in acute phase sera of spontaneous resolution versus persistent hepatitis C virus infection.
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检测自发消退与持续性丙型肝炎病毒感染的急性期血清中的宿主免疫反应。
DOI：
10.1099/vir.0.041277-0
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Busch,MichaelP
中科院分区：
文献类型：
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作者：
Selvarajah,Suganya;Keating,Sheila;Heitman,John;Lu,Kai;Simmons,Graham;Norris,PhilipJ;Operskalski,Eva;Mosley,JamesW;Busch,MichaelP
在丙型肝炎病毒（HCV）被发现之前，输血传播很常见。已知感染日期的受试者的病毒传播使研究急性丙型肝炎病毒感染的免疫反应成为可能。我们分析了输注传播HCV受试者血清样本中的39种可溶性免疫因子。观察急性HCV感染期间干扰素γ诱导蛋白10 （IP-10）、肿瘤坏死因子- α和白细胞介素-10的动态表达动力学。与未感染的对照组相比，血清IP-10是HCV解决者中唯一显著升高的分析物。在进展为慢性HCV的个体中，IP-10和IL-10水平升高与第一次显著的丙氨酸转氨酶升高同时发生，并在急性HCV感染的第一年保持升高。除了监测病毒载量减少的不足，急性丙型肝炎感染期间血清IP-10和IL-10表达水平可能是预测慢性丙型肝炎进展的有用生物标志物。
Prior to the identification of hepatitis C virus (HCV), transfusion-transmission was common. Viral transmission in subjects with a known date of infection allows the study of the immune responses to acute HCV infection. We analysed 39 soluble immune factors in serum samples from subjects with transfusion-transmitted HCV. Dynamic expression kinetics of interferon gamma-induced protein 10 (IP-10), tumour necrosis factor-alpha and interleukin (IL)-10 were observed during acute HCV infection. Serum IP-10 was the only analyte that was significantly elevated in HCV resolvers compared with uninfected controls. In individuals who progressed to chronic HCV elevated levels of IP-10 and IL-10 coincided with first significant alanine aminotransferase elevation and remained elevated during the first year of acute HCV infection. In addition to monitoring lack of reduction in viral load, serum levels of IP-10 and IL-10 expression during acute HCV infection may be useful biomarkers to predict the progress to chronic HCV.