Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig
Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig
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DOI：
10.1016/s0014-2999(03)01367-0
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发表时间：
2003-03-07
影响因子：
5
通讯作者：
Yamashita, H
中科院分区：
文献类型：
--
作者：
Horiike, O;Shimogori, H;Yamashita, H
本研究研究了依达拉奉对豚鼠链霉素诱导的前庭毒性的缓解作用。依达拉奉是一种自由基清除剂，具有很强的自由基淬灭作用，临床上用于治疗脑梗死。链霉素经内耳渗透泵给药24 h，依达拉奉（n = 8）或生理盐水（n = 6）腹腔注射，1次/d，共7 d。我们观察了水平前庭眼反射作为术后前庭功能的标志。注射生理盐水的动物的增重在统计学上小于注射依达拉奉的动物。这些结果表明，依达拉奉抑制链霉素诱导的前庭毒性。(C)2003 Elsevier Science B. V.保留所有权利。
This study investigated alleviation of streptomycin-induced vestibulotoxicity by edaravone in guinea pigs. Edaravone, a free radical scavenger, has potent free radical quenching action and is used in clinical practice to treat cerebral infarction. Streptomycin was administered to the inner ear by osmotic pump for 24 h, and edaravone (n = 8) or saline (n = 6) was intraperitoneally injected once a day for 7 days. We observed horizontal vestibulo-ocular reflex as a marker of postoperative vestibular function. Animals injected with saline showed statistically smaller gains than those injected with edaravone. These results suggest that edaravone suppresses streptomycin-induced vestibulotoxicity. (C) 2003 Elsevier Science B.V. All rights reserved.