The novel function of nesfatin-1: Anti-hyperglycemia
The novel function of nesfatin-1: Anti-hyperglycemia
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DOI：
10.1016/j.bbrc.2009.12.014
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Liu, Jian-Ning
中科院分区：
文献类型：
--
作者：
Su, Yijing;Zhang, Jing;Liu, Jian-Ning
Nesfatin-1是一种饱腹感分子，通过中枢和外周注射下丘脑中的黑皮质素信号传导抑制食物摄入。在这里，我们报告nesfatin-1也是抗高血糖。发现静脉注射nesfatin-1显著降低高血糖db/db小鼠的血糖。nesfatin-1的这种抗高血糖作用具有时间、剂量、胰岛素依赖性和外周性。(C)2009 Elsevier Inc. All rights reserved.
Nesfatin-1 is recently reported as a satiety molecule to suppress food intake via the melanocortin signaling in hypothalamus when injected centrally and peripherally. Here we report that nesfatin-1 is also anti-hyperglycemic. It was found that the intravenous injection of nesfatin-1 significantly reduced blood glucose in hyperglycemic db/db mice. This anti-hyperglycemic effect of nesfatin-1 was time-, dose-, insulin-dependent and peripheral. (C) 2009 Elsevier Inc. All rights reserved.