Epileptic source localization with high density EEG: how many electrodes are needed?
Epileptic source localization with high density EEG: how many electrodes are needed?
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DOI：
10.1016/s1388-2457(02)00337-1
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发表时间：
2003-01-01
影响因子：
4.7
通讯作者：
Michel, CM
中科院分区：
文献类型：
--
作者：
Lantz, G;de Peralta, RG;Michel, CM
目的：脑电(EEG)源重建是一种有效的非侵入性定位癫痫灶的方法。然而，大阵列脑磁图(MEG)系统在相当长的一段时间内就可以使用了，但应用上的困难以前阻碍了多通道脑电记录。然而，最近，允许快速(10-20分钟)施加多达125个电极并从其记录的EEG系统已经变得可用。本研究的目的是系统地比较高电极密度和稀疏电极设置的癫痫源定位的准确性。对14例接受术前评估的癫痫患者用123个电极记录电活动。每一张都是癫痫样。将电势降至63个和31个电极，并使用分布式源模型(EPIFOCUS)重建具有3种不同电极配置的源。结果：在9/14例患者中，63个电极到病变部位的距离明显小于31个电极，而增加到123个电极的患者数量从9个增加到11个。模拟结果证实了电极数量与定位精度的关系。结论：结果表明，对于癫痫患者，多通道脑电记录对于高来源定位精度是必要的。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Objective: Electroencephalography (EEG) source reconstruction is becoming recognized as a useful technique to non-invasively localize the epileptic focus. Whereas, large array magnetoencephalography (MEG) systems are available since quite some time, application difficulties have previously prevented multichannel EEG recordings. Recently, however, EEG systems which allow for quick (10-20 min) application of, and recording from, up to 125 electrodes have become available. The purpose of the current investigation was to systematically compare the accuracy of epileptic source localization with high electrode density to that obtained with sparser electrode setups.Methods: Interictal epileptiform. activity was recorded with 123 electrodes in 14 epileptic patients undergoing presurgical evaluation. Each single epileptiform. potential was down sampled to 63 and 31 electrodes, and a distributed source model (EPIFOCUS) was used to reconstruct the sources with the 3 different electrode configurations. The localization accuracy with the 3 electrode setups was then assessed, by determining the distance from the inverse solution, maximum of each single spike to the epileptogenic lesion.Results: In 9/14 patients, the distance from the EEG source to the lesion was significantly smaller with 63 than with 31 electrodes, and increasing the number of electrodes to 123 increased this number of patients from 9 to 11. Simulations confirmed the relation between the number of electrodes and localization accuracy.Conclusions: The results illustrate the necessity of multichannel EEG recordings for high source location accuracy in epileptic patients. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.