Fabrication, Characterization, and Biocompatibility of Polymer Cored Reduced Graphene Oxide Nanofibers
Fabrication, Characterization, and Biocompatibility of Polymer Cored Reduced Graphene Oxide Nanofibers
复制标题
聚合物核还原氧化石墨烯纳米纤维的制备、表征和生物相容性
DOI：
10.1021/acsami.6b00243
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发表时间：
2016-03-02
影响因子：
9.5
通讯作者：
Wang, Zhenling
中科院分区：
文献类型：
--
作者：
Jin, Lin;Wu, Dingcai;Wang, Zhenling
石墨烯纳米纤维在包括生物、能源和环境等众多领域都展现出了良好的应用潜力。然而，由于石墨烯尺寸分布广泛且溶解性极差，石墨烯纳米纤维的制备仍然是一个具有挑战性的问题。在此，我们报道了一种简便而有效的方法，通过将氧化石墨烯片直接热驱动自组装到电纺聚合物纳米纤维表面，无需任何表面处理，制备了一类新型的聚合物核 - 还原氧化石墨烯壳纳米纤维垫（RGO - CSNFM）。如此制备的RGO - CSNFM表现出优异的机械、电学和生物相容性。与没有纳米纤维结构的独立RGO薄膜相比，RGO - CSNFM还促进了人骨髓间充质干细胞（hMSCs）更高的细胞贴附和增殖。此外，hMSCs的细胞活力与组织培养板（TCPs）上的相当，且具有独特的健康形态，这表明纳米纤维结构在支持细胞活动方面起着至关重要的建设性作用。此外，RGO - CSNFM表现出优异的导电性，使其成为导电细胞培养、生物传感和组织工程应用的理想候选材料。这些发现可为制备用于生物医学应用的明确的石墨烯基纳米材料结构和界面提供一个新的标准。
Graphene nanofibers have shown a promising potential across a wide spectrum of areas, including biology, energy, and the environment. However, fabrication of graphene nanofibers remains a challenging issue due to the broad size distribution and extremely poor solubility of graphene. Herein, we report a facile yet efficient approach for fabricating a novel class of polymer core-reduced graphene oxide shell nanofiber mat (RGO-CSNFM) by direct heat driven self-assembly of graphene oxide sheets onto the surface of electrospun polymeric nanofibers without any requirement of surface treatment. Thus prepared RGO-CSNFM demonstrated excellent mechanical, electrical, and biocompatible properties. RGO-CSNFM also promoted a higher cell anchorage and proliferation of human bone marrow mesenchymal stem cells (hMSCs) compared to the free-standing RGO film without the nanoscale fibrous structure. Further, cell viability of hMSCs was comparable to that on the tissue culture plates (TCPs) with a distinctive healthy morphology, indicating that the nanoscale fibrous architecture plays a critically constructive role in supporting cellular activities. In addition, the RGO-CSNFM exhibited excellent electrical conductivity, making them an ideal candidate for conductive cell culture, biosensing, and tissue engineering applications. These findings could provide a new benchmark for preparing well-defined graphene-based nanomaterial configurations and interfaces for biomedical applications.