Platelets as an indicator of vascular repair in elderly Japanese men.
Platelets as an indicator of vascular repair in elderly Japanese men.
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DOI：
10.18632/oncotarget.10229
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发表时间：
2016-07-19
期刊：
影响因子：
--
通讯作者：
Maeda T
中科院分区：
文献类型：
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作者：
Shimizu Y;Sato S;Koyamatsu J;Yamanashi H;Nagayoshi M;Kadota K;Maeda T
据报道，血小板和循环 CD34 阳性细胞有助于血管修复（内皮修复和动脉粥样硬化）。并且由于已知高血压是一种强烈的血管损害因素，因此它也应该影响这些因素各自的数量。为了阐明血小板对血管修复的临床重要性，我们对 567 名 60-69 岁的日本男性进行了一项横断面研究，这些男性在 2013 年至 2015 年间接受了年度健康检查。对非高血压受试者调整经典心血管危险因素的多元线性回归分析表明，尽管血小板计数与颈动脉内膜中层厚度没有显着相关性（β = -0.05，p = 0.356），但呈正相关。与循环 CD34 阳性细胞数量的自然对数显着相关（β = 0.26，p < 0.001）。在高血压受试者中，血小板与内膜中层厚度之间存在显着正相关性（β = 0.19，p = 0.008），而血小板计数与循环 CD34 阳性细胞数量的自然对数之间没有显着相关性（β = 0.11，p = 0.119）。我们的结果表明，血小板计数是血管修复活性（内皮修复和动脉粥样硬化发展）的指标。此外，高血压可能掩盖循环 CD34 阳性细胞的有益作用。
Platelets and circulating CD34-positive cells have been reported to contribute to vascular repair (endothelial repair and developing atherosclerosis). And because hypertension is known to be a strong vascular impairment factors, it should also influence the respective numbers of these factors. To clarify the clinical importance of platelets on vascular repair, we conducted a cross-sectional study of 567 Japanese men aged 60-69 who underwent an annual health check-up between 2013 and 2015. Multiple linear regression analysis of non-hypertensive subjects adjusting for classical cardiovascular risk factors showed that although platelet count did not significantly correlate with carotid intima media thickness (β = −0.05, p = 0.356), it did positively correlate significantly with the natural log of the number of circulating CD34-positive cells (β = 0.26, p < 0.001). In hypertensive subjects, a significant positive correlation was seen between platelets and intima media thickness (β = 0.19, p = 0.008), whereas no significant correlation was seen between platelet count and the natural log of the number of circulating CD34-positive cells (β = 0.11, p = 0.119). Our results indicate that platelet count is an indicator of vascular repair activity (endothelial repair and developing atherosclerosis). Additionally, hypertension might mask the beneficial effects of circulating CD34-positive cells.