The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment
The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment
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DOI：
10.1111/j.1651-2227.2009.01653.x
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发表时间：
2010-04-01
期刊：
影响因子：
3.8
通讯作者：
Blennow, M.
中科院分区：
文献类型：
--
作者：
Hallberg, B.;Grossmann, K.;Blennow, M.
背景：72 小时诱导中度低温 (HT) 已被证明可以减少窒息足月婴儿死亡或严重神经发育障碍的综合结果。出生后 3-6 小时的病理振幅积分脑电图背景已被证明与不良预后相关。 目的：本研究的目的是探讨 HT 治疗期间的振幅积分脑电图与患有中/重度缺氧缺血性脑病的窒息足月婴儿的短期结局之间的相关性。方法：2006 年 12 月至 2007 年 12 月期间，24 名婴儿接受了中度 HT 治疗。 （33.5 摄氏度，72 小时）使用冷却床垫。在4月龄和12月龄时评估运动功能。结果：在28,837名婴儿的总出生队列中，26名婴儿符合HT治疗标准（0.9/1000），其中23名婴儿接受了HT治疗，并且所有这些婴儿都有可用的振幅积分脑电图数据。 10/15 的婴儿在 6 小时内出现严重异常爆发抑制模式或更严重的情况时，1 岁结果正常。研究发现，严重异常可显着预测 36 小时后的异常结果。结论：在接受 HT 治疗的窒息婴儿中，只有出生后 24 小时及以上持续存在 aEEG 异常的婴儿在 1 岁时表现出较差的神经系统结果。
Background:Induced moderate hypothermia (HT) for 72 h has been shown to reduce the combined outcome of death or severe neurodevelopmental disabilities in asphyxiated full-term infants. A pathological amplitude integrated EEG background as early as 3-6 h after birth, has been shown to correlate to poor prognosis.Aim:The aim of this study was to investigate the correlation between amplitude integrated EEG during HT treatment and short-term outcome in asphyxiated full-term infants with moderate/severe hypoxic-ischaemic encephalopathy.Methods:Between December 2006 and December 2007, 24 infants were treated with moderate HT (33.5 degrees C for 72 h) using a cooling mattress. Motor functions were assessed at 4 and 12 months of age.Results:Of the total birth cohort of 28,837 infants, 26 infants fulfilled the criteria for HT treatment (0.9/1000) of whom 23 was treated with HT and all of these infants had available amplitude integrated EEG data. Normal 1-year outcome was found in 10/15 infants with severely abnormal burst-suppression pattern or worse at 6 h of age. Severe abnormalities were found to be significantly predictive for abnormal outcome after 36 h.Conclusion:Among asphyxiated infants treated with HT, only those who had aEEG abnormalities persisting at and beyond 24 h after birth showed poor neurological outcome at 1 year.