A PROPOSED ANIMAL-MODEL FOR HALLUCINOGENS BASED ON LSDS EFFECTS ON PATTERNS OF EXPLORATION IN RATS
A PROPOSED ANIMAL-MODEL FOR HALLUCINOGENS BASED ON LSDS EFFECTS ON PATTERNS OF EXPLORATION IN RATS
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DOI：
10.1037/0735-7044.99.5.881
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发表时间：
1985-01-01
影响因子：
1.9
通讯作者：
GEYER, MA
中科院分区：
文献类型：
--
作者：
ADAMS, LM;GEYER, MA
为了建立致幻药动物模型，对大鼠探索活动的各种方法进行了研究。通过门连接到饲养笼的孔板室提供了两种测试情况。将大鼠直接放入门关闭的孔板中（强制探索），或将其放入饲养笼中，适应后打开门（自由探索）。监测系统提供了定量措施（交叉，rearings，和孔戳）和定性措施的运动模式。用2-160 μ g/kg LSD的剂量进行的一系列四个实验揭示了三种主要类型的作用，其可根据剂量依赖性、时间过程或对环境操作的反应来区分：（a）增加对新区域和中心区域的回避，（B）破坏运动的空间模式，和（c）抑制直立。所有三种效应在一次注射30 μ g/kg LSD后24小时表现出部分耐受性，并且在每天注射五次后表现出完全耐受性。LSD增强大鼠的新恐惧症的可能性可能是一个有效的模拟模型，其在人类的情感反应的加剧进行了讨论。
The utility of various measures of exploratory activty in rats was studied in order to develop an animal model of hallucinogens. A hole board chamber, connected by a door to a home cage, provided two test situations. Rats either were placed directly into the hole board with the door clowed (forced exploration) or were placed in the home cage and, following adaptation, the door was opened (free exploration). The monitoring system provided both quantitative measures (crossovers, rearings, and hole pokes) and qualitative measures of locomotor patterns. A series of four experiments, with doses of 2-160 .mu.g/kg LSD, revealed three major categories of effects, distinguishable on the basis of dose dependency, time course, or response to environmental manipulation: (a) increased avoidance of novel and central areas, (b) disruption of the spatial patterning of locomotion, and (c) suppression of rearing. All three effects exhibited partial tolerance 24 hr after one injection of 30 .mu.g/kg LSD and complete tolerance after five daily injections. The possibility that LSD''s enhancement of neophobia in rats may be a valid analogue model of its intensification of affective reactions in humans is discussed.