Schematic representation of residue-based protein context-dependent data: An application to transmembrane proteins
Schematic representation of residue-based protein context-dependent data: An application to transmembrane proteins
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DOI：
10.1016/s1093-3263(99)00032-7
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发表时间：
1999-06-01
影响因子：
2.9
通讯作者：
Weinstein, H
中科院分区：
文献类型：
--
作者：
Campagne, F;Weinstein, H
提出并说明了一种在2D页面上绘制基于残基的蛋白质示意图的算法方法。该方法允许创建专用于给定序列家族或折叠的渲染引擎。初始实现提供了可以产生表示任何跨膜蛋白质序列的二级结构的2D图的引擎。我们提出的策略，自动绘制这些图的细节，这个策略的最重要的部分是一个算法的开发，用于布局连接到任意点的一个循环的残留物的2D平面。实现后，该算法适用于回路布局的实时修改。这项工作是感兴趣的数据表示和分析（1）蛋白质数据库，（2）诱变结果，或（3）各种蛋白质上下文相关的注释或数据。(C)2000年，Elsevier Science Inc.
An algorithmic method for drawing residue-based schematic diagrams of proteins on a 2D page is presented and illustrated. The method allows the creation of rendering engines dedicated to a given family of sequences, or fold The initial implementation provides an engine that can produce a 2D diagram representing secondary structure for any trans-membrane protein sequence. We present the details of the strategy for automating the drawing of these diagrams, The most important part of this this strategy is the development of an algorithm for laying out residues of a loop that connects to arbitrary points of a 2D plane. As implemented, this algorithm is suitable for real-time modification of the loop layout. This work is of interest for the representation and analysis of data from (I) protein databases, (2) mutagenesis results, or (3) various kinds of protein context-dependent annotations or data. (C) 2000 by Elsevier Science Inc.