Echocardiographically detected dyskinesis, myocardial infarct size, and coronary risk region relationships in reperfused canine myocardium.
Echocardiographically detected dyskinesis, myocardial infarct size, and coronary risk region relationships in reperfused canine myocardium.
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超声心动图检测再灌注犬心肌中的运动障碍、心肌梗塞面积和冠状动脉危险区域关系。
DOI：
10.1161/01.cir.71.6.1292
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发表时间：
1985
期刊：
影响因子：
37.8
通讯作者：
R. Kerber
中科院分区：
文献类型：
--
作者：
Anne L. Taylor;R. Kieso;J. Melton;P. Hite;N. Pandian;R. Kerber
永久性冠状动脉闭塞后，二维超声心动图检测到运动障碍的程度与梗死面积密切相关。冠状动脉闭塞后再灌注减少梗死面积；然而，以这种方式挽救的心肌收缩功能可能会持续数周。本研究的目的是探讨超声心动图检测到的再灌注心肌运动障碍与梗死面积之间的关系。我们假设短暂性冠状动脉闭塞后，由于再灌注后收缩功能的长期抑制，运动障碍与梗死面积之间的关系会发生改变，因此运动障碍不能预测梗死面积。我们还想探讨两个相关的问题：(1)再灌注心肌的肌力刺激是否会改善功能不全但未坏死的节段收缩功能？(2)梗死面积与冠状动脉危险区之间的关系，在永久性冠状动脉闭塞的心肌中是线性的，在连续闭塞和再灌注的心肌中是否仍然是线性的？37只注射了镇静剂并预先放置了旋转闭塞器的狗进行了1或2小时的冠状动脉闭塞，然后进行了2或10天的再灌注。通过对照、闭塞1或2小时后、再灌注20分钟后、再灌注2或10天后获得的索索肌和乳头肌水平的短轴二维超声心动图估计左心室运动障碍的百分比。在再灌注2天或10天，同时在输注多巴酚丁胺时获得超声心动图。死后钡明胶血管造影确定危险区域，病理检查确定梗死面积。我们发现再灌注心肌梗死面积和危险区面积之间存在显著的线性相关。（摘要删节250字）
After permanent coronary artery occlusion, the extent of two-dimensional echocardiographically detected dyskinesis correlates well with infarct size. Reperfusion after coronary artery occlusion decreases infarct size; however, contractile function of myocardium salvaged in this way may remain depressed for several weeks. The purpose of this study was to explore the relationship between echocardiographically detected dyskinesis and infarct size in reperfused myocardium. We hypothesized that after transient coronary artery occlusion, the relationship between dyskinesis and infarct size would be altered because of the prolonged depression of contractile function after reperfusion so that dyskinesis would not predict infarct size. We also wanted to explore two related questions: (1) Does inotropic stimulation of reperfused myocardium result in improved systolic function in segments that are dysfunctional but not necrotic? (2) Does the relationship between infarct size and coronary risk region, which is linear in myocardium subjected to permanent coronary occlusion, remain linear in myocardium subjected to a sequence of occlusion and reperfusion? Thirty-seven sedated dogs with preplaced circumflex occluders underwent 1 or 2 hr of coronary artery occlusion, then 2 or 10 days of reperfusion. The percentage of the left ventricle that was dyskinetic was estimated from short-axis two-dimensional echocardiograms at the chordal and papillary muscle level obtained at control, after 1 or 2 hr of occlusion, after 20 min of reperfusion, and after 2 or 10 days of reperfusion. At 2 or 10 days of reperfusion, echocardiograms were also obtained during infusion of dobutamine. Area at risk was determined from postmortem barium-gelatin angiography and infarct size was determined at pathologic examination. We found a significant linear correlation between infarct size and risk region size in reperfused myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)
在心肌梗死发展过程中，冠状动脉内给予链激酶可持续改善左心室功能和死亡率。
影响因子：
37.8
作者：
Smalling,RW;Fuentes,F;Matthews,MW;Freund,GC;Hicks,CH;Reduto,LA;Walker,WE;Sterling,RP;Gould,KL
通讯作者：
Gould,KL
犬早期实验性急性心肌梗塞二维超声心动图左心室壁运动与心肌挽救之间的分离。
DOI：
10.1016/s0002-9149(84)80224-6
发表时间：
1984
期刊：
The American journal of cardiology
影响因子：
--
作者：
Hammerman,H;O'Boyle,JE;Cohen,C;Kloner,RA;Parisi,AF
通讯作者：
Parisi,AF