DEFICITS IN NACL INGESTION AFTER DAMAGE TO THE CENTRAL NUCLEUS OF THE AMYGDALA IN THE RAT
DEFICITS IN NACL INGESTION AFTER DAMAGE TO THE CENTRAL NUCLEUS OF THE AMYGDALA IN THE RAT
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DOI：
10.1016/0361-9230(92)90234-o
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发表时间：
1992-01-01
影响因子：
3.8
通讯作者：
EPSTEIN, AN
中科院分区：
文献类型：
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作者：
GALAVERNA, O;DELUCA, LA;EPSTEIN, AN
这些研究检测了双侧杏仁中央核(CeAX)电解性损毁大鼠的食盐摄取行为。CeAX取消了每日3%氯化钠的免费摄入量，即使在手术前因反复钠耗竭而增加，但在术后连续三次钠耗竭后略有恢复的大鼠也是如此。CeAX大鼠在高剂量DOCA和脑血管紧张素II的激活下喝水，但不喝3%的氯化钠，术后钠耗竭后表现出少量但可靠的盐摄入量(需要诱导的盐摄入量或食盐量)。其他进食行为(饮水、进食和5%蔗糖)均正常。当给予浓度降低的氯化钠溶液时，CeAX大鼠拒绝接受它们，直到浓度达到0.2%。这些发现表明，杏仁核中央核的损伤导致了盐摄取行为的整体损害，这可能是由于盐味信号的中央处理的改变。
These studies examined the NaCl intake behaviors of rats with bilateral electrolytic lesions of the central nucleus of the amygdala (CeAX). Daily need-free intake of 3% NaCl was abolished by CeAX even in rats in which it had been enhanced preoperatively by a history of repeated sodium depletions but was slightly restored by three successive postoperative sodium depletions. CeAX rats drank water but not 3% NaCl to high doses of DOCA and to the activation of cerebral angiotensin II, and expressed small but reliable salt intake (need-induced salt intake or salt appetite) after postoperative sodium depletions. Other ingestive behaviors (water drinking, intake of food and 5% sucrose) were normal. When given decreasing concentrations of NaCl solution the CeAX rats rejected them until the concentration reached 0.2%. These findings suggest that lesions to the central nucleus of the amygdala produce a global impairment in salt intake behaviors that is possibly due to an alteration in the central processing of the salt taste signal.