Modulation of fibroblast growth factor-2 by stress and corticosteroids: from developmental events to adult brain plasticity
Modulation of fibroblast growth factor-2 by stress and corticosteroids: from developmental events to adult brain plasticity
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DOI：
10.1016/s0165-0173(01)00128-x
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发表时间：
2001-11-01
影响因子：
--
通讯作者：
Riva, MA
中科院分区：
文献类型：
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作者：
Molteni, R;Fumagalli, F;Riva, MA
神经营养因子是一类在不同发育阶段对大脑功能起重要作用的多肽。碱性成纤维细胞生长因子-2是其中的一种，在发育中的脑和成人脑中都有高表达。它的表达可以在不同的实验情况下进行调节，这可能与细胞的脆弱性和大脑的可塑性有关。应激和糖皮质激素对大脑功能产生短期和长期的影响，这可能涉及对选定大脑结构中特定神经营养因子的调节。皮质酮或地塞米松治疗可上调大鼠不同脑区以及培养的星形胶质细胞中成纤维细胞生长因子-2的表达。在急性束缚应激后，在几个大脑区域也观察到类似的成纤维细胞生长因子-2生物合成的升高。这种反应是快速和短暂的，由于成纤维细胞生长因子-2具有神经保护作用，可能代表了一种防御机制，通过这种机制，大脑可以随着时间的推移限制压力的有害影响。此外，胚胎后期(E18-E20)暴露于皮质酮可显着降低成年雄性大鼠海马区成纤维细胞生长因子-2的mRNA水平，并改变其对应激或皮质酮的急性调节作用。这些数据表明，在大脑成熟过程中发生的应激相关事件可以调节特定脑区内成纤维细胞生长因子-2的表达，从而导致永久性的结构和功能变化，从而增加对挑战性生活事件的易感性。(C)2001 Elsevier Science B.V.保留所有权利。
Neurotrophic factors are a heterogeneous group of peptides that play important roles on brain function at different development stages. Basic fibroblast growth factor (FGF-2), one of these molecules, is highly expressed in developing and adult brain. Its expression can be regulated under different experimental situations and this may be relevant for cellular vulnerability and brain plasticity. Stress and glucocorticoid hormones produce short- and long-term effects on brain function, which can involve the regulation of specific neurotrophic factors within selected brain structures. Treatments with corticosterone or dexamethasone up-regulate FGF-2 expression in different rat brain regions as well as in cultured astroglial cells. A similar elevation of FGF-2 biosynthesis is also observed in several brain regions following an acute restraint stress. This response is rapid and transient and, as FGF-2 is neuroprotective, may represent a defense mechanism through which the brain may limit the deleterious effect of stress over time. Moreover exposure to corticosterone during late stage of embryonic life (E18-E20) produces a significant reduction of FGF-2 mRNA levels in the adult hippocampus of male rats as well as changes in its acute modulation in response to stress or corticosterone. These data suggest that stress-related events taking place during brain maturation can modulate the expression of FGF-2 within selected brain regions thus contributing to permanent structural and functional alterations leading to an increased vulnerability to challenging life events. (C) 2001 Elsevier Science B.V. All rights reserved.