Enhancement of mice susceptibility to infection with Listeria monocytogenes by the treatment of morphine
Enhancement of mice susceptibility to infection with Listeria monocytogenes by the treatment of morphine
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DOI：
10.1111/j.1348-0421.2006.tb03824.x
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Makino, Sou-ichi
中科院分区：
文献类型：
--
作者：
Asakura, Hiroshi;Kawamoto, Keiko;Makino, Sou-ichi
通过腹腔接种法观察吗啡对BALB/c小鼠对大肠杆菌、志贺菌、单核细胞增生李斯特菌、沙门氏菌、小肠结肠炎耶尔森菌的敏感性的影响。吗啡处理增加了对S.肠杆菌和L.在吗啡处理的小鼠中，与单核细胞增多性李斯特菌的感染，导致菌血症和中枢神经系统（CNS）侵入（对于单核细胞增多性李斯特菌），而与其他细菌的感染没有显示出系统性传播。值得注意的是，单核细胞增生李斯特菌感染导致吗啡治疗小鼠100%死亡，平均生存时间（MST）为1.3天，但未治疗的小鼠并未死亡。目前的数据表明，使用海洛因或吗啡衍生物治疗的个体可能具有高风险，尤其是那些免疫功能低下的人。最近吗啡消费量的增加可能表明有必要对传染病进行进一步的流行病学监测。
The effect of morphine on the susceptibility of BALB/c mice to diarrheagenic Escherichia coli, Shigella flexneri, Listeria monocytogenes, Salmonella Enteritidis, Yersinia enterocolitica, was examined via the intraperitoneal inoculation. Morphine treatment increased the susceptibility to S. Enteritidis and L. monocytogenes, resulting in bacteremia and central nervous system (CNS) invasion (for L monocytogenes), while the infection with other bacteria did not show the systemic dissemination in the morphine-treated mice. Notably, L monocytogenes infection caused 100% mortality with a mean survival time (MST) of 1.3 days in morphine-treated mice, but untreated mice did not die. The present data suggested that individuals using heroin or treated with morphine derivatives might be at high risk for listeriosis, especially those who are immunocompromised. Recent increasing consumption of morphine may propose the necessity for further epidemiological surveillance on infectious diseases.