Serotonin receptors in depression: from A to B.
Serotonin receptors in depression: from A to B.
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DOI：
10.12688/f1000research.9736.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Hen R
中科院分区：
文献类型：
--
作者：
Nautiyal KM;Hen R
5-羟色胺在抑郁症(MDD)中的作用一直是临床和临床前研究的焦点。这些研究的结果反映了在许多大脑区域和整个生命周期中，5-羟色胺通过许多受体发出信号的复杂性。5-羟色胺转运体在MDD中的作用已经在基因与环境相关的研究中得到了强调，以及它在最有效的抗抑郁药物-选择性5-羟色胺再摄取抑制剂的机制中的关键作用。虽然已知的15种5-羟色胺受体中的大多数都与抑郁或抑郁样行为有关，但5-羟色胺1A(5-HT1A)和1B(5-HT1B)受体是研究最多的受体之一。人脑成像和遗传学研究指出，5-HT1A和5-HT1B受体参与了MDD以及对抗抑郁药物治疗的反应。在啮齿动物中，组织特异性和可诱导的基因敲除小鼠品系的获得使得以细胞类型特异性的方式鉴定5-HT1A和5-HT1B受体在整个发育过程中的参与成为可能。这项研究以及其他临床前药理学工作表明，这些受体的自体受体和异源受体群体在调节抑郁相关行为以及对抗抑郁药物的反应方面具有不同的作用，并且在出生后早期发育期间的功能也不同于成年时期。
The role of serotonin in major depressive disorder (MDD) is the focus of accumulating clinical and preclinical research. The results of these studies reflect the complexity of serotonin signaling through many receptors, in a large number of brain regions, and throughout the lifespan. The role of the serotonin transporter in MDD has been highlighted in gene by environment association studies as well as its role as a critical player in the mechanism of the most effective antidepressant treatments – selective serotonin reuptake inhibitors. While the majority of the 15 known receptors for serotonin have been implicated in depression or depressive-like behavior, the serotonin 1A (5-HT 1A) and 1B (5-HT 1B) receptors are among the most studied. Human brain imaging and genetic studies point to the involvement of 5-HT 1A and 5-HT 1B receptors in MDD and the response to antidepressant treatment. In rodents, the availability of tissue-specific and inducible knockout mouse lines has made possible the identification of the involvement of 5-HT 1A and 5-HT 1B receptors throughout development and in a cell-type specific manner. This, and other preclinical pharmacology work, shows that autoreceptor and heteroreceptor populations of these receptors have divergent roles in modulating depression-related behavior as well as responses to antidepressants and also have different functions during early postnatal development compared to during adulthood.