Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster
Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster
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DOI：
10.1177/0748730402239673
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发表时间：
2003-02-01
影响因子：
3.5
通讯作者：
Sehgal, A
中科院分区：
文献类型：
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作者：
Hendricks, JC;Lu, SM;Sehgal, A
通常认为中央时钟提供休息/活动的计时信息，但不参与这些状态的调节。为了检验作为分子钟组成部分的基因也调节休息的假设，作者量化了导致心律失常运动行为的中央时钟的四种可行果蝇突变体和缺乏色素分散因子（一种输出神经肽）的 pdf 突变体的综合休息和活动的持续时间和强度。只有循环 (cyc(01)) 和时钟 (Clk(lrk)) 突变体具有映射到突变位点的异常，即，巩固休息减少和活动时间大幅延长。除 cyc(01) 果蝇外，所有突变体在休息剥夺后均表现出正常的补偿性反弹。 cyc(01) 中的这种异常反应具有性别二态性，在雄性中减弱或不存在，在雌性中增强。最后，cyc(01)突变缩短了雄性果蝇的寿命。这些数据表明，周期调节雄性果蝇的休息和寿命。
The central clock is generally thought to provide timing information for rest/activity but not to otherwise participate in regulation of these states. To test the hypothesis that genes that are components of the molecular clock also regulate rest, the authors quantified the duration and intensity of consolidated rest and activity for the four viable Drosophila mutations of the central clock that lead to arrhythmic locomotor behavior and for the pdf mutant that lacks pigment-dispersing factor, an output neuropeptide. Only the cycle (cyc(01)) and Clock (Clk(lrk)) mutants had abnormalities that mapped to the mutant locus, namely, decreased consolidated rest and grossly extended periods of activity. All mutants with the exception of the cyc(01) fly exhibited a qualitatively normal compensatory rebound after rest deprivation. This abnormal response in cyc(01) was sexually dimorphic, being reduced or absent in males and exaggerated in females. Finally, the cyc(01) mutation shortened the life span of male flies. These data indicate that cycle regulates rest and life span in male Drosophila.