Facilitatory transmitters and cAMP can modulate accommodation as well as transmitter release in Aplysia sensory neurons: Evidence for parallel processing in a single cell.
Facilitatory transmitters and cAMP can modulate accommodation as well as transmitter release in Aplysia sensory neurons: Evidence for parallel processing in a single cell.
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协助递质和 cAMP 可以调节海兔感觉神经元的调节和递质释放：单细胞并行处理的证据。
DOI：
10.1073/pnas.83.20.7994
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发表时间：
1986
影响因子：
11.1
通讯作者：
E. Kandel
中科院分区：
文献类型：
--
作者：
M. Klein;B. Hochner;E. Kandel
从感觉神经元到运动神经元的突触前易化对防御性退缩反射的行为敏感化有重要贡献。突触前易化作用与突触前肽敏感性K（+）电导的降低有关。这种减少扩大了突触前动作电位。此外，引起易化的程序-刺激连接（从尾部和头部的通路），应用调节性递质或注射cAMP-也增加了感觉神经元的兴奋性，如用细胞内去极化脉冲注射到细胞体中所测试的。增加的兴奋性反映在产生动作电位的阈值降低和对长时间恒定电流刺激的适应性降低。通过影响感觉神经元的外周过程的兴奋性，刺激连接物或5-羟色胺也产生感觉神经元对施加到虹吸管的触觉刺激的响应的小增强。兴奋性变化似乎至少部分是由导致动作电位增宽的相同细胞机制引起的，这是cAMP介导的K（+）通道关闭。因此，这些研究结果表明，同一类机制，原则上，有一个双重的行动，并提供进一步的证据，并行处理的调制递质释放从一个单一的神经元。
Presynaptic facilitation of transmission from sensory to motor neurons contributes significantly to behavioral sensitization of defensive withdrawal reflexes in Aplysia. Presynaptic facilitation is associated with a decrease in the serotonin-sensitive K(+) conductance. This decrease broadens the presynaptic action potential. In addition, the procedures that cause facilitation-stimulation of the connective (the pathway from the tail and head), application of modulatory transmitters, or injection of cAMP-also increase the excitability of the sensory neurons as tested with intracellular depolarizing pulses injected into the cell body. The increased excitability is reflected in a decreased threshold for generating action potentials and a reduction in accommodation to prolonged constant current stimuli. By influencing the excitability of the peripheral processes of the sensory neurons, stimulation of the connectives or serotonin also produces a small enhancement of the response of the sensory neurons to a tactile stimulus applied to the siphon. The excitability changes appear to result, at least in part, from the same cellular mechanisms that lead to broadening of the action potential, a cAMP-mediated closure of K(+) channels. Therefore, these findings indicate that the same class of mechanisms can, in principle, have a dual action and provide further evidence for parallel processing in the modulation of transmitter release from a single neuron.