A comprehensive and critical overview of schistosomiasis vaccine candidates.
A comprehensive and critical overview of schistosomiasis vaccine candidates.
复制标题
血吸虫病候选疫苗的全面和批判性概述。
DOI：
10.1007/s12639-021-01387-w
复制
发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Mahana N
中科院分区：
文献类型：
--
作者：
Al-Naseri A;Al-Absi S;El Ridi R;Mahana N
血吸虫病是一种被忽视的热带疾病，在中东、撒哈拉以南非洲、南美洲和中国的许多国家影响人类和动物。为预防感染或治疗急性和慢性疾病，采用了几种控制方法。大规模药物管理导致严重感染和发病率下降，但未能降低血吸虫病流行率和消除传播，这表明需要开发抗寄生虫疫苗来预防感染和寄生虫传播。本文对血吸虫病疫苗的免疫效果和保护力进行了综述，并对今后的发展进行了展望。
A digenetic platyhelminth Schistosoma is the causative agent of schistosomiasis, one of the neglected tropical diseases that affect humans and animals in numerous countries in the Middle East, sub-Saharan Africa, South America and China. Several control methods were used for prevention of infection or treatment of acute and chronic disease. Mass drug administration led to reduction in heavy-intensity infections and morbidity, but failed to decrease schistosomiasis prevalence and eliminate transmission, indicating the need to develop anti-schistosome vaccine to prevent infection and parasite transmission. This review summarizes the efficacy and protective capacity of available schistosomiasis vaccine candidates with some insights and future prospects.