Temperature-Dependent Dielectric Properties of Human Bone Constituents at THz Frequencies: Contrast Mechanisms and Bound Water Dynamics
Temperature-Dependent Dielectric Properties of Human Bone Constituents at THz Frequencies: Contrast Mechanisms and Bound Water Dynamics
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DOI：
10.1109/irmmw-thz50927.2022.9896085
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发表时间：
2022-08
期刊：
影响因子：
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通讯作者：
N. Chopra;N. Shaw;L. Lotkowska;C. Sui;M. Navarro‐Cía;J. Lloyd‐Hughes
中科院分区：
文献类型：
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作者：
N. Chopra;N. Shaw;L. Lotkowska;C. Sui;M. Navarro‐Cía;J. Lloyd‐Hughes
利用太赫兹时域光谱技术（THz-TDS）研究了人体骨组织成分的介电特性。我们报告的折射率和吸收系数的四个主要的无水骨成分：胶原蛋白，羟基磷灰石，方解石和无定形磷酸钙的实验值。我们改变了样品的温度，以探索这些成分的太赫兹介电函数的物理机制。实验数据进行了很好的描述，分别使用德拜模型的胶原蛋白，或洛伦兹模型的矿物质化合物。为了提取弛豫时间和振子强度等拟合参数，采用粒子群优化算法进行拟合。
THz time domain spectroscopy (THz-TDS) was used to investigate the dielectric properties of constituents of human bone. We report experimental values for refractive index and absorption coefficient for four major anhydrous constituents of bone: Collagen, Hydroxyapatite, Calcite and Amorphous calcium phosphate. We varied the sample temperature in order to explore the physical mechanisms underpinning the THz dielectric function of these constituents. Experimental data were well described using the Debye model for collagen, or the Lorentz model for mineral compounds, respectively. A fitting procedure based on Particle Swarm Optimization was implemented in order to extract the fitting parameters such as relaxation times and oscillator strengths.