Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography
Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography
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DOI：
10.1016/j.tetlet.2009.01.142
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发表时间：
2009-07-01
影响因子：
1.8
通讯作者：
Shibasaki, Masakatsu
中科院分区：
文献类型：
--
作者：
Kimura, Yasuaki;Yamatsugu, Kenzo;Shibasaki, Masakatsu
通过修改我们原有的磷酸奥司他韦（达菲）的合成路线，合成了与达菲核心连接的树脂。制备的树脂结合流感病毒酶神经氨酸酶，达菲的主要目标。固定的达菲类似物将用于分离和鉴定与达菲相互作用的假定内源性脊椎动物蛋白，这可能与用达菲治疗的一些流感患者所表现出的异常行为有关。(C)2009爱思唯尔有限公司保留所有权利。
A resin linked with the Tamiflu core was synthesized by modifying our original synthetic route Of oseltamivir phosphate (Tamiflu). The prepared resin bound to the influenza virus enzyme neuraminidase, the main target of Tamiflu. The immobilized Tamiflu analog will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the abnormal behavior exhibited by some influenza patients treated with Tamiflu. (C) 2009 Elsevier Ltd. All rights reserved.