Emergence of a new disease as a result of interspecific virulence gene transfer
Emergence of a new disease as a result of interspecific virulence gene transfer
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DOI：
10.1038/ng1839
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发表时间：
2006-08-01
期刊：
影响因子：
30.8
通讯作者：
Oliver, Richard P.
中科院分区：
文献类型：
--
作者：
Friesen, Timothy L.;Stukenbrock, Eva H.;Oliver, Richard P.
人类、动物和植物的新疾病经常出现。通过获得新的毒力因子可以促进对新宿主的毒力增强。已知种间基因转移是细菌病原体中此类毒力因子的来源（通常在受体生物体中表现为致病岛（1）），并且推测毒力因子的种间转移可能发生在真菌病原体中（2）。到目前为止，还没有直接的证据支持这一假设。在这里，我们提出的证据表明，一个基因编码的关键毒力因子被转移到另一种真菌病原体从一个物种。这种基因转移可能发生在1941年之前，创造了一个致病力显著增强的病原体群体，并导致了一种新的小麦破坏性疾病的出现。
New diseases of humans, animals and plants emerge regularly. Enhanced virulence on a new host can be facilitated by the acquisition of novel virulence factors. Interspecific gene transfer is known to be a source of such virulence factors in bacterial pathogens (often manifested as pathogenicity islands in the recipient organism(1)) and it has been speculated that interspecific transfer of virulence factors may occur in fungal pathogens(2). Until now, no direct support has been available for this hypothesis. Here we present evidence that a gene encoding a critical virulence factor was transferred from one species of fungal pathogen to another. This gene transfer probably occurred just before 1941, creating a pathogen population with significantly enhanced virulence and leading to the emergence of a new damaging disease of wheat.