Pax6 influences the time and site of origin of glial precursors in the ventral neural tube
Pax6 influences the time and site of origin of glial precursors in the ventral neural tube
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DOI：
10.1006/mcne.1998.0711
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发表时间：
1998-11-01
影响因子：
3.5
通讯作者：
Smith, HK
中科院分区：
文献类型：
--
作者：
Sun, T;Pringle, NP;Smith, HK
脊髓腹侧脑室区（VZ）的神经上皮前体产生运动神经元（MN）和中间神经元，然后前体的子集开始产生少突胶质细胞祖细胞（OLP）。我们发现，OLP起源于腹侧最部分的Pax 6阳性VZ，在较早的时候产生体细胞（Isl 2/Lim 3阳性）MN。在小眼（Pax 6缺陷）小鼠中，OLP的起源向背侧移位，并且OLP和Isl 2/Lim 3 MN均延迟。我们认为，体细胞MNs和OLP产生顺序从一组共同的MN-OL前体，其位置在VZ的影响Pax 6。神经胶质细胞命运转换可能是这些前体细胞的一种预先编程的特性，或者是对新产生的神经元反馈的一种反应。OLs在Isl 1（-/-）脊髓的外植体中正常发育，缺乏MN，反对反馈控制，并表明神经元-胶质细胞开关是神经前体特定子集中的内在发育程序。
Neuroepithelial precursors in the ventral ventricular zone (VZ) of the spinal cord generate motor neurons (MNs) and interneurons, and then a subset of precursors starts to produce oligodendrocyte progenitors (OLPs). We show that OLPs originate in the ventral-most part of the Pax6-positive VZ, which at earlier times generates somatic (Isl2/Lim3-positive) MNs. In Small eye (Pax6-deficient) mice, the origin of OLPs is shifted dorsally and both OLPs and Isl2/Lim3 MNs are delayed. We suggest that somatic MNs and OLPs are generated sequentially from a common set of MN-OL precursors whose position in the VZ is influenced by Pax6. Neuron-glia fate switching might be a preprogrammed property of these precursors or a response to feedback from newly generated neurons. OLs developed normally in explants of Isl1(-/-) spinal cords, which lack MNs, arguing against feedback control and suggesting that the neuron-glia switch is an intrinsic developmental program in a specific subset of neural precursors.